| 摘要: |
| 目的：探讨蒋益兰教授治疗乳腺癌的用药规律。方法：筛选整理2022年9月至2023年4月蒋教授门诊治疗乳腺癌的处方，采用古今医案云平台（V2.3.5）进行中药频次、属性、归经、功效、复杂网络和聚类等分析。结果：共纳入300首方剂，150味中药，累计使用频次为5266次，获得甘草、茯苓、百合、郁金、黄芪、半夏、白花蛇舌草、半枝莲、党参、白术、枳壳、女贞子、墨旱莲、灵芝、首乌藤15味核心药物，药味以甘、苦、辛、酸为主，药性以平性为主，主要归肝、脾、肺、心经，功效以清热解毒、滋补肝肾、燥湿化痰为主。中药复杂网络分析得到核心组方药物为：百合、党参、黄芪、茯苓、半夏、白花蛇舌草、半枝莲、白术、郁金。聚类分析获得4首聚类方。结论：蒋教授治疗乳腺癌多从肝郁、脾虚、冲任失和入手，采用疏肝解郁、燥湿化痰、补益肝脾、调理冲任之法，可取得佳效。 |
| 关键词: 乳腺癌 蒋益兰 用药规律 数据挖掘 |
| DOI： |
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| Medication rule of Jiang Yilan in treatment of breast cancer：A study based on data mining |
| PENG Siyuan,SONG Cheng,TANG Wei |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;Hunan Cancer Hospital，Changsha 410031，Hunan，China;Hunan Hospital of Integrated Traditional Chinese and Western Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of Professor Jiang Yilan in the treatment of breast cancer.Methods：The prescriptions for the treatment of breast cancer were collected from the outpatient service of Professor Jiang from September 2022 to April 2023，and Cloud Platform of Ancient and Modern Medical Records was used to perform the analysis of traditional Chinese medicine (TCM) drugs in terms of frequency，attributes，meridian entry，and function，as well as complex network analysis and cluster analysis.Results：A total of 300 prescriptions were included，involving 150 TCM drugs，with a cumulative frequency of use of 5266 times.A total of 15 core drugs were obtained，i.e.，Radix Glycyrrhizae，Poria cocos，lily，Curcuma aromatica，Astragalus membranaceus，Pinellia ternata，Hedyotis diffusa，Scutellaria barbata，Codonopsis pilosula，Atractylodes macrocephala Koidz.，Fructus Aurantii，Fructus Ligustri Lucidi，Herba Ecliptae，Ganoderma lucidum，and Caulis Polygoni Multiflori.Most drugs were neutral in nature and had a sweet，bitter，pungent，or sour taste，and they main entered the liver，spleen，lung，and heart meridians.Their main functions included clearing heat and detoxicating，tonifying the liver and the kidney，and drying dampness and resolving phlegm.The complex network analysis of the TCM drugs obtained the drugs for the core prescription，i.e.，lily，Codonopsis pilosula，Astragalus membranaceus，Poria cocos，Pinellia ternata，Hedyotis diffusa，Scutellaria barbata，Atractylodes macrocephala Koidz.，and Curcuma aromatic.The cluster analysis obtained 4 cluster prescriptions.Conclusion：In the treatment of breast cancer，Professor Jiang often starts from stagnation of liver Qi，spleen deficiency，and Chong-Ren impairment and applies the methods of soothing the liver and resolving stagnation，drying dampness and resolving phlegm，tonifying the liver and the spleen，and regulating Chong-Ren，which can help to achieve a good clinical effect. |
| Key words: breast cancer Jiang Yilan medication rule data mining |
