| 摘要: |
| 目的：基于数据挖掘技术探讨中药坐浴治疗慢性非细菌性前列腺炎（CNP）的用药规律，为中医药治疗CNP提供参考。方法：检索自建库至 2022 年12月7日中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）、中国生物医学文献服务系统（SinoMed）、PubMed中有关中药坐浴治疗CNP的临床研究文献，建立处方数据库，采用 SPSS Modeler 18.0 Apriori算法进行关联规则分析并绘制高频中药共现网络图；采用 SPSS Statistics 25.0对中药进行层次聚类分析并绘制树状图。结果：共纳入文献129篇，提取中药处方148首，涉及中药201味，累计使用频次1414次，其中高频中药共20味，排前5位的依次为黄柏、丹参、大黄、败酱草、蒲公英；药性以寒为主，药味以苦为主，多归肝、心、胃经；在中药配伍方面，丹参-黄柏支持度最高；高频中药可分为7个聚类群。结论：中药坐浴治疗CNP以清热利湿、活血化瘀为主，兼顾益气扶正，体现了中医扶正祛邪、标本兼顾的治疗原则。 |
| 关键词: 慢性非细菌性前列腺炎 中药坐浴 用药规律 数据挖掘 |
| DOI： |
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| Medication rule of traditional Chinese medicine sitz bath in treatment of chronic nonbacterial prostatitis：A study based on data mining |
| WANG Li,ZHAO Ruicheng,ZHU Wei |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;Hunan Hospital of Integrated Traditional Chinese and Western Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of traditional Chinese medicine (TCM) sitz bath in the treatment of chronic nonbacterial prostatitis (CNP) based on data mining，and to provide a reference for the TCM treatment of CNP.Methods：CNKI，Wanfang Data，VIP，SinoMed，and PubMed were searched for clinical research articles in TCM sitz bath in the treatment of CNP published up to December 7，2022，and a database was established for the prescriptions.SPSS Modeler 18.0 Apriori algorithm was used to perform association rule analysis and plot the co-occurrence network of high-frequency TCM drugs，and SPSS Statistics 25.0 was used to perform a hierarchical cluster analysis of TCM drugs and plot a tree diagram.Results：A total of 129 articles were included，from which 148 TCM prescriptions were extracted，involving 201 TCM drugs，with a cumulative frequency of use of 1414 times.There were 20 high-frequency drugs，and the top 5 drugs were Phellodendri Chinensis Cortex，Salvia miltiorrhiza，Rheum officinale，Herba Patriniae，and dandelion.Most drugs were cold in nature and had a bitter taste，and they mainly entered the liver，heart，and stomach meridians.As for the compatibility of TCM drugs，the highest degree of support was observed in Salvia miltiorrhiza-Phellodendri Chinensis Cortex.The high-frequency drugs could be clustered into 7 groups.Conclusion：In the treatment of CNP，TCM sitz bath mainly applies the heat-clearing and diuresis-promoting therapy and the blood-activating and stasis-resolving therapy，with consideration to the method of tonifying Qi and strengthening vital Qi，which reflects the TCM treatment principles of strengthening vital Qi，eliminating pathogen，and addressing both the symptoms and root causes. |
| Key words: chronic nonbacterial prostatitis traditional Chinese medicine sitz bath medication rule data mining |
