| 摘要: |
| 目的：通过串联审视田曾流派治案之药、方证与诊法联系规律，明晰其脉法体系与临证辨治模式。方法：以田曾流派存世医案为基础，建立田曾流派“脉象-方证-症状-处方-药物”数据库。采用IBM SPSS Modeler 18.0软件中的Apriori算法对脉-方证、脉-症、症-方及症-药进行关联规则分析，并运用Cytoscape 3.7.2软件对关联结果进行可视化展示。结果：共纳入田曾流派医案275个，其中脉-方证关联规则中置信度最高的是脉沉有力→调胃承气汤（100.00%）；脉-症规则中置信度最高的是脉弦长→肠鸣辘辘（100.00%）、脉浮缓→纳呆（100.00%）及脉沉弦→头晕（100.00%）；置信度较高的症-方规则主要集中于半夏泻心汤证；症-药关联中置信度最高的为小便灼热→滑石（100.00%）、心悸→甘草（100.00%）及心悸+头晕→甘草（100.00%）。结论：田曾流派以脉象定方药，以脉象联症状，将“脉-方证-药”体系及“脉-症-方药”体系有机融入临床实践中，形成“脉象-方证-症状-处方-药物”五位一体之独特辨治模式，对经方之临床实践具有指导意义。 |
| 关键词: 蜀地伤寒 田曾流派 关联规则 脉-方证 脉-症 症-方 症-药 |
| DOI： |
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| Pattern of syndrome differentiation-based treatment of typhoid fever in Sichuan Province of China by Tian-Zeng Academic School：A study based on data mining |
| ZHANG Huize,ZHANG Qi,WEN Yulong |
| (The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，Sichuan，China;Chengdu University of Traditional Chinese Medicine，Chengdu 610075，Sichuan，China) |
| Abstract: |
| Objective：To investigate the pulse manifestation system and pattern of syndrome differentiation-based treatment in clinical practice by examining the association between medicine，syndrome，and diagnostic method used by Tian-Zeng Academic School.Methods：A “pulse manifestation-syndrome-symptom-prescription-drug” database was established for Tian-Zeng Academic School based on the existing medical records of Tian-Zeng Academic School.The Apriori algorithm in IBM SPSS Modeler 18.0 software was used to perform an association rule analysis of pulse manifestation-syndrome，pulse manifestation-symptom，symptom-prescription，and symptom-drug，and the results were visualized using Cytoscape 3.7.2 software.Results：A total of 275 medical records of Tian-Zeng Academic School were included.As for the pulse manifestation-syndrome association rule，strong sunken pulse→Tiaowei Chengqi decoction had the highest confidence of 100.00%；for the pulse manifestation-symptom association rule，long and wiry pulse→borborygmus，floating moderate pulse→poor appetite，and deep wiry pulse→dizziness had the highest confidence of 100.00%；for the symptom-prescription association rule，Banxia Xiexin decoction and related syndromes had a relatively high confidence；for the symptom-drug association rule，burning sensation during urination→talc，palpitation→Radix Glycyrrhizae，and palpitation+dizziness→Radix Glycyrrhizae the highest confidence of 100.00%.Conclusion：Tian-Zeng Academic School determines prescriptions and drugs based on pulse manifestation，associates pulse manifestation with symptoms，and integrates the “pulse manifestation-syndrome-drug” system and the “pulse manifestation-symptom-prescription” system into clinical practice，to form the unique “pulse manifestation-syndrome-symptom-prescription-drug” pattern for syndrome differentiation-based treatment，which has certain guiding significance for the clinical application of classical prescriptions. |
| Key words: typhoid fever in Sichuan Province Tian-Zeng Academic School association rule pulse manifestation-syndrome pulse manifestation-symptom symptom-prescription symptom-drug |
