| 摘要: |
| 目的：观察健脾解毒消癌方治疗晚期卵巢癌的临床疗效。方法：选择60 例晚期卵巢癌患者作为研究对象，随机分为治疗组和对照组，每组各30 例。对照组采用多西他赛与卡铂联合化疗方案治疗，治疗组在此基础上联合健脾解毒消癌方治疗。观察2组实体瘤疗效、免疫功能及不良反应。结果：实体瘤疗效有效率治疗组为76.66%（23/30），对照组为56.67%（17/30），2组比较，差异有统计学意义（P<0.05）；治疗后治疗组CD3+、CD4+、CD4+/CD8+水平高于治疗前，CD8+水平低于治疗前，而对照组CD3+、CD4+、CD4+/CD8+水平低于治疗前，CD8+水平高于治疗前，治疗后组间比较，差异均有统计学意义（P<0.05）；治疗组中白细胞、血小板减少情况均优于对照组，胃肠道反应、神经毒性发生率均低于对照组，组间比较，差异均有统计学意义（P<0.05）。结论：对晚期卵巢癌患者采用健脾解毒消癌方联合化疗方案治疗获得显著疗效，并能提高患者免疫功能，且不良反应少，可资临床借鉴。 |
| 关键词: 晚期卵巢癌 中西医结合疗法 化疗方案 健脾解毒消癌方 |
| DOI： |
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| Clinical effect of Jianpi Jiedu Xiaoai prescription in treatment of advanced ovarian cancer：An analysis of 30 cases |
| CHEN Siming,LIU Renque |
| (The Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Jianpi Jiedu Xiaoai prescription in the treatment of advanced ovarian cancer.Methods：A total of 60 patients with advanced ovarian cancer were enrolled as subjects and randomly divided into treatment group and control group，with 30 patients in each group.The patients in the control group were given chemoradiotherapy regimen with docetaxel and carboplatin，and those in the treatment group were given Jianpi Jiedu Xiaoai prescription in addition to the treatment in the control group.The two groups were observed in terms of solid tumor response，immune function，and adverse reactions.Results：There was a significant difference in the response rate of solid tumor between the treatment group and the control group ［76.66% (23/30) vs 56.67% (17/30)，P<0.05］.After treatment，the treatment group had significant increases in the levels of CD3+，CD4+，and CD4+/CD8+ and a significant reduction in the level of CD8+，while the control group had significant reductions in the levels of CD3+，CD4+，and CD4+/CD8+ and a significant increase in the level of CD8+，and there were significant differences in these indices between the two groups after treatment (P<0.05).Compared with the control group，the treatment group had significantly better conditions of leukopenia and thrombocytopenia and significantly lower incidence rates of gastrointestinal reactions and neurotoxicity (P<0.05).Conclusion：Jianpi Jiedu Xiaoai prescription combined with a chemotherapy regimen has a marked clinical effect in patients with advanced ovarian cancer and can improve their immune function with little adverse effect，and therefore，it holds promise for clinical application. |
| Key words: advanced ovarian cancer integrated traditional Chinese and Western medicine therapy chemoradiotherapy regimen Jianpi Jiedu Xiaoai prescription |
