| 摘要: |
| 目的：研究慢性萎缩性胃炎（CAG）中医证型与癌变风险的相关性。方法：将2016—2020年在广州市番禺区中医院消化内科就诊的1020 例CAG患者进行回顾性研究，分析患者中医证候及分布规律，比较不同证型患者的肠上皮化生率、上皮瘤变率和Hp感染率。结果:脾胃湿热证、肝脾不和证的肠上皮化生率及上皮瘤变率均高于脾胃虚弱证、胃阴不足证、胃络瘀血证，差异均有统计学意义（P＜0.01）；脾胃湿热证、肝脾不和证、胃络瘀血证的Hp感染率高于脾胃虚弱证、胃阴不足证，差异均有统计学意义（P＜0.01）。logictic回归分析结果显示，肠上皮化生、上皮瘤变、Hp感染均为CAG癌变的单影响因素（P＜0.05）。结论：不同中医证型的CAG患者癌变风险存在差异，中医证型的运用对癌变风险的临床评估具有一定的参考意义。 |
| 关键词: 慢性萎缩性胃炎 证型 癌变风险 相关性 |
| DOI： |
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| Association between traditional Chinese medicine syndrome type and risk of carcinogenesis in chronic atrophic gastritis |
| LI Qiangbin,AN Yun,CHEN Weigang |
| (Panyu Hospital of Traditional Chinese Medicine，Guangzhou 511400，Guangdong，China) |
| Abstract: |
| Objective:To investigate the association between traditional Chinese medicine (TCM) syndrome type and risk of carcinogenesis in chronic atrophic gastritis (CAG).Methods：A retrospective analysis was performed for 1020 patients with CAG who attended Department of Gastroenterology，Panyu Hospital of Traditional Chinese Medicine，from 2016 to 2020，and TCM syndromes and their distribution were analyzed.Intestinal metaplasia rate，intraepithelial neoplasia rate，and Helicobacter pylori (Hp) infection rate were compared between the patients with different syndrome types.Results：The patients with spleen-stomach damp-heat syndrome or incoordination between the liver and the spleen had significantly higher intestinal metaplasia rate and intraepithelial neoplasia rate than those with deficiency of spleen and stomach，stomach-Yin deficiency，or blood stasis in stomach collaterals (P＜0.01)，and the patients with spleen-stomach damp-heat syndrome，incoordination between the liver and the spleen，or blood stasis in stomach collaterals had a significantly higher Hp infection rate than those with deficiency of spleen and stomach or stomach-Yin deficiency (P＜0.01).The logistic regression analysis showed that intestinal metaplasia，intraepithelial neoplasia，and Hp infection were single influencing factors for CAG carcinogenesis (P＜0.05).Conclusion：The risk of carcinogenesis varies among CAG patients with different TCM syndrome types，and the application of TCM syndrome types provides a certain reference for clinical evaluation of the risk of carcinogenesis. |
| Key words: chronic atrophic gastritis syndrome type risk of carcinogenesis association |
