| 摘要: |
| 目的：探讨接受中医药治疗的艾滋病（AIDS）患者CD4/CD8变化的影响因素。方法：选取“云南省中医药治疗艾滋病试点项目数据库”中接受中医药治疗达12个月，治疗前后均做过CD4+T淋巴细胞、CD8+T淋巴细胞检测，人口学数据完整的847 例患者，采用Logistic回归分析法分析CD4/CD8变化的影响因素。结果：年龄小、治疗前CD4+T淋巴细胞计数和CD4/CD8较低，中医药介入时已经开始高效抗逆转录治疗（HAART）的艾滋病毒（HIV）/AIDS患者，中医药治疗后CD4/CD8上升的可能性更大；而女性、治疗前CD4+T淋巴细胞计数和CD4/CD8较高，中医药介入时已经开始HAART治疗的HIV/AIDS患者，中医药治疗12个月后CD4/CD8处于正常范围的可能性更大。结论：尽早对患者采用中医药联合HAART的治疗方案有助于患者CD4/CD8的恢复，对存在不利因素的HIV/AIDS患者，应针对性地给予治疗，以提高疗效。 |
| 关键词: 艾滋病 中医药 CD4/CD8 影响因素 回归性分析 |
| DOI： |
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| A regression analysis of the influencing factors for CD4/CD8 in AIDS patients receiving traditional Chinese medicine treatment |
| SUN Jun,WANG Li,YANG Yuqi |
| (Yunnan Institute of Traditional Chinese Medicine，Kunming 650223，Yunnan，China) |
| Abstract: |
| Objective：To investigate the influencing factors for the change in CD4/CD8 in AIDS patients receiving traditional Chinese medicine treatment.Methods：Based on the database of Yunnan Provincial Pilot Project on Traditional Chinese Medicine Treatment of AIDS，a total of 847 patients with complete demographic data who received traditional Chinese medicine treatment for at least 12 months and underwent the measurement of CD4+T lymphocytes and CD8+T lymphocytes before and after treatment were enrolled，and the logistic regression analysis was used to investigate the influencing factors for the change in CD4/CD8.Results：The HIV/AIDS patients with a relatively young age，relatively low CD4+T lymphocyte count and CD4/CD8 ratio before treatment，and highly active antiretroviral therapy (HAART) initiated before traditional Chinese medicine intervention tended to have a higher possibility of increase in CD4/CD8 ratio after treatment.The HIV/AIDS patients with HAART initiated before traditional Chinese medicine intervention tended to have a higher possibility of CD4/CD8 ratio within the normal range after 12 months of traditional Chinese medicine treatment.Conclusion：Traditional Chinese medicine treatment combined with HAART should be performed as early as possible to help with the recovery of CD4/CD8 ratio，and targeted treatment should be given to HIV/AIDS patients with adverse factors to improve their treatment outcome. |
| Key words: AIDS traditional Chinese medicine CD4/CD8 influencing factor regression analysis |
