| 摘要: |
| 目的：观察头风汤治疗瘀血型慢性偏头痛（CM）的临床疗效及其对血液流变学的影响。方法：将80 例瘀血型CM患者随机分为治疗组与对照组，每组各40 例。治疗组予头风汤治疗，对照组予盐酸氟桂利嗪胶囊治疗，疗程均为3个月。比较2组患者临床症状积分、血液流变学指标改善情况及不良反应，根据临床症状积分评价综合疗效。结果：总有效率治疗组为90.00%（36/40），对照组为67.50%（27/40），2组比较，差异有统计学意义（P＜0.05）；2组临床症状积分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05）；治疗组治疗后血液流变学指标改善程度优于对照组，差异有统计学意义（P＜0.05）；2组均未出现明显不良反应。结论：头风汤治疗瘀血型CM疗效良好，能明显改善患者临床症状及血液流变学状态，且无明显不良反应。 |
| 关键词: 慢性偏头痛 瘀血证 头风汤 盐酸氟桂利嗪 |
| DOI： |
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| Clinical effect of Toufeng decoction in treatment of chronic migraine with blood stasis and its influence on hemorheology |
| XU Hui,CHEN Jianhong |
| (Changsha Fourth Hospital，Changsha 410006，Hunan，China;Hengyang Hospital of Traditional Chinese Medicine，Hengyang 421001，Hunan，China) |
| Abstract: |
| Objective:To investigate the clinical effect of Toufeng decoction in the treatment of chronic migraine (CM) with blood stasis and its influence on hemorheology.Methods:A total of 80 patients with CM with blood stasis were randomly divided into treatment group and control group，with 40 patients in each group.The patients in the treatment group were given Toufeng decoction，and those in the control group were given flunarizine hydrochloride capsules；the course of treatment was 3 months for both groups.The two groups were compared in terms of clinical symptom score，improvement in hemorheological indices，and adverse reactions，and overall response was evaluated based on clinical symptom score.Results:There was a significant difference in overall response rate between the treatment group and the control group ［90.00% (36/40) vs 67.50% (27/40)，P＜0.05］.Both groups had a significant change in clinical symptom score after treatment，and there was a significant difference in clinical symptom score between the two groups after treatment (P＜0.05).Compared with the control group，the treatment group had significantly better improvements in hemorheological indices after treatment (P＜0.05).No obvious adverse reactions were observed in either group.Conclusion:Toufeng decoction has a good clinical effect in the treatment of CM with blood stasis and can significantly improve patients’ clinical symptoms and hemorheological status，with little adverse effect. |
| Key words: chronic migraine blood stasis Toufeng decoction flunarizine hydrochloride |
