| 摘要: |
| 目的：探究煜鹤堂蝮蛇酒对血糖血脂和血压的调节作用。方法：将检疫合格的SD大鼠、自发性高血压（SHR）大鼠随机分为正常对照组、模型对照组、溶媒对照组及煜鹤堂蝮蛇酒高、中、低剂量组（用药剂量分别相当于成人推荐食用量的20、10和5倍）。SD大鼠除正常对照组外，其余各组大鼠给予定量高脂高糖饲料喂养，同时按10ml/kg给予受试物或溶媒，连续4周，末次给样后检测血糖（GLU）以及血清中总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（LDL-C）及低密度脂蛋白（HDL-C）水平。SHR大鼠按10ml/kg灌胃给予受试物4周，每周检测各组大鼠体质量和血压。结果：煜鹤堂蝮蛇酒各剂量均可显著降低高糖高脂模型大鼠GLU和TC水平（P<0.01），高、中剂量可显著降低模型大鼠TG及LDL-C水平（P<0.01或P<0.05）；煜鹤堂蝮蛇酒高剂量可明显降低SHR大鼠收缩压（P<0.05），对实验动物体质量无明显影响。结论：煜鹤堂蝮蛇酒具有明显的降糖调脂和降压作用。 |
| 关键词: 煜鹤堂蝮蛇酒 血糖 血脂 血压 实验研究 |
| DOI： |
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| Antidiabetic，antihyperlipidemic，and antihypertensive effects of Yuhetang Agkistrodon halys medicinal liquor |
| SHAO Guoqiang,LIAO Guoqun,XU Linben |
| (Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China;Hunan Qunhong Biotechnology，Co.，Ltd.，Loudi 417199，Hunan，China) |
| Abstract: |
| Objective：To investigate the regulatory effect of Yuhetang Agkistrodon halys medicinal liquor on blood glucose，blood lipids，and blood pressure.Methods：Quarantined Sprague-Dawley (SD) rats and spontaneous hypertension rats (SHRs) were randomly divided into normal control group，model control group，solvent control group，and high-，middle-，and low-dose Yuhetang Agkistrodon halys medicinal liquor groups (the dose of the medicinal liquor was 20，10，and 5 times that recommended for adults).All SD rats except those in the normal control group were given a fixed amount of high-fat and high-glucose diet，and the test substance or solvent was given at a dose of 10ml/kg for 4 consecutive weeks；blood glucose (GLU) and serum levels of total cholesterol (TC)，triglyceride (TG)，low-density lipoprotein cholesterol (LDL-C)，and high-density lipoprotein cholesterol (HDL-C) were measured after the last administration.SHRs were given the test substance by gavage at a dose of 10 ml/kg，and body weight and blood pressure were measured every week.Results：Low-，middle-，and high-dose Yuhetang Agkistrodon halys medicinal liquor significantly reduced GLU and TC in the rat model of hyperglycemia and hyperlipidemia (P＜0.01)，while the high- and middle-dose medicinal liquor significant reduced TG and LDL-C in model rats (P＜0.01 or P＜0.05).High-dose Yuhetang Agkistrodon halys medicinal liquor significantly reduced systolic pressure in SHRs (P＜0.05) and had no marked influence on the body weight of experimental animals.Conclusion：Yuhetang Agkistrodon halys medicinal liquor has marked antidiabetic，antihyperlipidemic，and antihypertensive effects. |
| Key words: Yuhetang Agkistrodon halys medicinal liquor blood glucose blood lipids blood pressure experimental study |
