| 摘要: |
| 目的：研究天降血栓通丸对2型糖尿病大鼠血糖、大血管病变的影响。方法：将90只wistar大鼠随机分为正常组15只与造模组75只，通过高糖高脂饲料+链脲佐菌素诱导建立糖尿病大鼠模型，造模成功后将其随机分为模型组，天降血栓通丸早期干预组、中期干预组、晚期干预组（简称为早期组、中期组、晚期组），盐酸吡格列酮组（西药组），每组各15只，分别采用相应药物干预。观察大鼠一般情况，检测空腹血糖、胰岛素、胰岛素敏感指数、细胞间黏附分子-1（ICAM-1）水平。结果：造模组与空白组比较，胰岛素、胰岛素敏感指标、体质量、第13周空腹血糖差异均有统计学意义（P＜0.01或P＜0.05）；药物干预后空腹血糖水平ICAM-1模型组、各治疗组与空白组比较，各治疗组与模型组比较，差异均有统计学意义（P＜0.05）。结论：天降血栓通丸无降糖作用，其早期干预能有效降低ICAM-1，这可能是其对2型糖尿病大鼠大血管病变影响的机制之一。 |
| 关键词: 2型糖尿病大鼠 血糖 大血管病变 天降血栓通丸 |
| DOI： |
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| Clinical effect of Tianjiang Xueshuantong pills on blood glucose and macrovascular complications in rats with type 2 diabetes |
| XU Caifeng,MA Guohai |
| (Beichen Hospital of Traditional Chinese Medicine，Tianjin 300400，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Tianjiang Xueshuantong pills on blood glucose and macrovascular complications in rats with type 2 diabetes.Methods：A total of 90 Wistar rats were randomly divided into normal group with 15 rats and model group with 75 rats.High-sugar and high-fat feed and streptozotocin were used to establish a rat model of diabetes，and after the model was successfully established，the rats were divided into model group，early-，middle-，and late-stage Tianjiang Xueshuantong pill intervention groups（early-，middle-，and late-stage intervention groups，respectively)，and pioglitazone hydrochloride group（Western medicine group)，with 15 rats in each group.The rats were treated with corresponding drugs.General status of the rats was observed，and fasting blood glucose（FBG)，insulin，insulin sensitivity index（ISI)，and intercellular adhesion molecule-1（ICAM-1）were measured.Results：There were significant differences between the model group and the normal group in insulin，ISI，body weight，and FBG at week 13（P＜0.01 or P＜0.05).After drug intervention，there were significant differences in FBG and ICAM-1 between the model group/treatment groups and the normal group，as well as between the treatment groups and the model group（P＜0.05).Conclusion：Tianjiang Xueshuantong pills do not have a hypoglycemic effect，and its early intervention can effectively reduce ICAM-1，which might be one of the mechanisms of action of Tianjiang Xueshuantong pills in the treatment of macrovascular complications in rats with type 2 diabetes. |
| Key words: rat with type 2 diabetes blood glucose macrovascular complication Tianjiang Xueshuantong pill |
