| 摘要: |
| 目的：探讨疏风宣肺汤对慢性支气管炎大鼠p38MAPK/ATF-2信号转导通路的作用。方法：将SD大鼠随机分为空白对照组、模型组、疏风宣肺汤组、宣肺止嗽合剂组，采用混合烟雾吸入法建立慢性支气管炎大鼠模型，分别给予相应药物进行干预。检测各组大鼠p38MAPK蛋白表达含量、肺泡巨噬细胞计数、ATF-2蛋白表达含量。结果：疏风宣肺汤组能够明显降低p38MAPK蛋白表达含量、肺泡巨噬细胞计数及ATF-2蛋白表达含量，其治疗效果优于宣肺止嗽合剂组，差异均有统计学意义（P＜0.05）。结论:疏风宣肺汤可能是通过抑制p38MAPK/ATF-2信号通路表达，发挥对慢性支气管炎的治疗作用。 |
| 关键词: 慢性支气管炎 疏风宣肺汤 p38MAPK/ATF-2信号通路 |
| DOI： |
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| Effect of Shufeng Xuanfei decoction on the p38MAPK/ATF-2 signaling pathway in rats with chronic bronchitis |
| JIANG Ruoyu,MIN Rui,FAN Fuyuan |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China) |
| Abstract: |
| Objective：To investigate the effect of Shufeng Xuanfei decoction on the p38MAPK/ATF-2 signaling pathway in rats with chronic bronchitis.Methods：Sprague-Dawley rats were randomly divided into blank control group，model group，Shufeng Xuanfei decoction group，and Xuanfei Zhisou mixture group.A rat model of chronic bronchitis was established by smoke mixture inhalation，and the rats were given corresponding drugs for intervention.The protein expression of p38MAPK and ATF-2 and alveolar macrophage count were measured for all groups.Results：The Shufeng Xuanfei decoction group had significant reductions in the protein expression of p38MAPK and ATF-2 and alveolar macrophage count，as well as a significantly better treatment outcome，as compared with the Xuanfei Zhisou mixture group（P＜0.05).Conclusion：Shufeng Xuanfei decoction exerts a therapeutic effect on chronic bronchitis possibly by inhibiting the expression of the p38MAPK/ATF-2 signaling pathway. |
| Key words: chronic bronchitis Shufeng Xuanfei decoction p38MAPK/ATF-2 signaling pathway |
