| 摘要: |
| 目的：研究红藤瘀痛洗药经皮肤给药的毒性和安全性。方法：选用家兔进行皮肤急性毒性实验及皮肤刺激性实验，选用豚鼠进行皮肤过敏性实验，观察红藤瘀痛洗药的皮肤用药的急性毒性反应及皮肤刺激性、过敏性。结果：红藤瘀痛洗药高剂量、正常剂量对完整及破损家兔皮肤均未见急性毒性反应；红藤瘀痛洗药高剂量、正常剂量对家兔皮肤均未见刺激反应；红藤瘀痛洗药对豚鼠皮肤未见过敏反应。结论：红藤瘀痛洗药经皮肤给药无明显的毒性反应，安全性良好。 |
| 关键词: 红藤瘀痛洗药 急性毒性反应 刺激性反应 过敏性反应 |
| DOI： |
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| Dermal toxicity and safety of Hongteng Yutong lotion |
| WANG Ming-jian，,JU Shao-hua，,TAN You-li |
| (Sports Hospital Affiliated to Chengdu Sport Institute，Chengdu 610041，Sichuan，China) |
| Abstract: |
| Objective：To investigate the toxicity and safety of transdermal administration of Hongteng Yutong lotion.Methods：Rabbits were used to conduct dermal acute toxicity test and skin irritation test and guinea pigs were used to conduct skin allergy test，in order to observe the acute toxicity，skin irritation，and skin allergy of transdermal administration of Hongteng Yutong lotion.Results：Hongteng Yutong lotion at a high or normal dose did not have acute toxicity on intact and damaged rabbit skin or irritation on rabbit skin，and Hongteng Yutong lotion did not cause allergy on guinea pig skin.Conclusion：Transdermal administration of Hongteng Yutong lotion does not have marked toxicity and has good safety. |
| Key words: Hongteng Yutong lotion acute toxicity irritation allergic reaction |
