| 摘要: |
| 目的：基于聚类分析探索治疗多发性硬化的核心处方。方法：以“中药”“中医”“多发性硬化”为主题词进行检索，搜集中药治疗多发性硬化的相关文献，整理处方药物并建立Excel数据表，运用中医传承辅助平台V3.0对药物数据进行聚类分析。结果：检索到相关文献116篇，包含214个治疗多发性硬化的中药复方；涉及中药298味。使用频率最高的中药为黄芪，其次是当归、白术、山茱萸、熟地黄等，药物功效以补虚、活血化瘀为主，中药四气多为温、平、寒性，五味以甘、苦居多；归经以肝、脾、肾经为主；关联规则显示常用药对由黄芪、当归、白术、白芍、川芎、党参等药物组合而成。聚类分析发现6个核心处方，具有补血益气、活血化瘀、健脾利湿、滋补肝肾、清热解毒等功效。结论：治疗多发性硬化的复方药物以补虚、活血化瘀类为主，佐以清热解表、平肝息风、利水渗湿类，可为临床治疗多发性硬化拟方提供思路。 |
| 关键词: 多发性硬化 聚类分析 核心处方 |
| DOI： |
|
|
| Core prescriptions for multiple sclerosis based on cluster analysis |
| TAN Wenzhang,WU Dahua,LI Jing |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Changsha 410006，Hunan，China;Xiangya Hospital of Central South University，Changsha 410008，Hunan，China) |
| Abstract: |
| Objective: To investigate the core prescriptions for the treatment of multiple sclerosis based on cluster analysis.Methods: Related databases were searched with the subject words of “traditional Chinese medicine drugs”，“traditional Chinese medicine”，and “multiple sclerosis” to collect the articles on traditional Chinese medicine (TCM) drugs for the treatment of multiple sclerosis.The drugs in prescriptions were analyzed，and an Excel data table was established.Traditional Chinese Medicine Inheritance Support System V3.0 was used to perform a cluster analysis of the above data.Results: A total of 116 articles were obtained，with 214 compound TCM prescriptions and 298 TCM drugs for the treatment of multiple sclerosis.Astragalus membranaceus had the highest frequency of use，followed by Angelica sinensis，Atractylodes macrocephala Koidz.，Comus officinalis，and prepared Radix Rehmanniae，and tonifying deficiency，activating blood and resolving stasis were the main drug functions.Most drugs were warm，neutral or cold in nature and had a sweet or bitter taste，and they mainly entered the liver，spleen，and kidney meridians.The association rule analysis showed that commonly used drug combinations involved the drugs such as Astragalus membranaceus，Angelica sinensis，Atractylodes macrocephala Koidz.，Radix Paeoniae Alba，Rhizoma Chuanxiong，and Codonopsis pilosula.The cluster analysis obtained 6 core prescriptions，with the functions of tonifying blood and benefiting Qi，activating blood and resolving stasis，strengthening the spleen and promoting diuresis，nourishing liver and kidney，and clearing heat and detoxicating.Conclusion: Compound drugs for the treatment of multiple sclerosis mainly have the functions of tonifying deficiency，activating blood and resolving stasis，in combination with heat-clearing and exterior syndrome-relieving drugs，liver-pacifying and wind-extinguishing drugs，and diuresis-inducing and dampness-draining drugs，which provides ideas for prescriptions for the clinical treatment of multiple sclerosis. |
| Key words: multiple sclerosis cluster analysis core prescription |
