| 摘要: |
| 目的：研究湖南省不同地区灵芝中外源性污染物含量,并对其重金属及有害元素进行健康风险评估,以期为灵芝的质量检测提供依据。方法：按照2020年版《中华人民共和国药典》（简称《中国药典》）对灵芝中重金属及有害元素、农药及二氧化硫等外源性污染物含量进行测定,通过计算每日最大可耐受量（EDI）和靶标危害系数（THQ）对其中重金属及有害元素含量进行健康风险评估。结果：各批次灵芝中砷、镉、汞、铅的含量均符合《中国药典》的限量标准。仅1批灵芝中砷含量和3批灵芝中镉含量不符合相关食品标准。EDI结果未发现明显健康风险;THQ结果显示,1批灵芝存在潜在健康风险。农药及二氧化硫残留检测结果显示,6批灵芝中农药残留量不符合限量标准,1批灵芝二氧化硫残留量不符合食品限量标准。结论：灵芝作为食药物质,需要有效控制外源性污染物含量,并及时完善相关质量标准。 |
| 关键词: 灵芝 外源性污染物 重金属 有害元素 农药 二氧化硫 健康风险评估 |
| DOI： |
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| Content analysis and health risk assessment of exogenous pollutants in Ganoderma lucidum |
| LU Caiyang,KUANG Chuangfu,LIANG Xuejuan |
| (Hunan Center for Drug Evaluation and ADR Monitoring,Changsha 410013,Hunan,China;Hunan Academy of Chinese Medicine,Changsha 410006,Hunan,China) |
| Abstract: |
| Objective：To investigate the content of exogenous pollutants and the health risk of heavy metals and harmful elements in Ganoderma lucidum from different areas of Hunan,China,and to provide a basis for the quality assessment of Ganoderma lucidum. Methods：The content of the exogenous pollutants such as heavy metals,harmful elements,pesticides,and sulfur dioxide was measured according to Pharmacopoeia of The People’s Republic of China (2020 edition) (hereinafter referred to as Chinese Pharmacopoeia),and EDI and target hazard quotient (THQ) were calculated to perform the health risk assessment of heavy metals and harmful elements. Results：The content of arsenic,cadmium,mercury,and lead in each batch of Ganoderma lucidum met the limit standard in Chinese Pharmacopoeia. It was found that the content of arsenic in one batch and the content of cadmium in three batches did not meet related food standard. The results of EDI showed no obvious health risks,while the results of THQ showed that one batch of Ganoderma lucidum had potential health risks. Detection of pesticide and sulfur dioxide residues showed that pesticide residues did not meet the limit standard in six batches of Ganoderma lucidum,and sulfur dioxide residues did not meet the limit standard for food in one batch. Conclusion：Since Ganoderma lucidum is both a drug and a type of food,it is necessary to effectively control the content of exogenous pollutants and timely perfect related quality standard. |
| Key words: Ganoderma lucidum heavy metal harmful element pesticide sulfur dioxide health risk assessment |
