| 摘要: |
| 目的：通过数据挖掘分析《王旭高临证医案》“痰饮篇”的处方用药，探寻王旭高治疗痰饮的用药规律。方法：运用SPSS 25.0、SPSS Modeler 18进行频数、性味归经、中药种类、聚类、因子和关联规则分析。结果：通过整理得到处方55首，共使用药物104味，总使用频次597次，高频药物（频次≥11次）共14味，频率从高到低依次为茯苓、半夏、陈皮、白术、甘草、干姜、桂枝、熟地黄、附子、杏仁、五味子、人参、款冬花、泽泻；104味药物按功效分类法收录并分类的共96味，涉及药物种类17种，使用频率最高的药物为补益药与化痰止咳平喘药；性味归经统计结果显示，药味以苦、甘、辛为主，药性多温；归经以肺、脾、肾、胃经为主；关联分析得出常用药对35组；对高频药物进行聚类分析与因子分析，得到3个类方，5个公因子。结论：王旭高辨治痰饮以温化为总则，重视肾脏对痰饮尤其是虚痰的影响，不畏滋腻，助肾纳气，兼以临证化裁，对当今临床仍具参考价值。 |
| 关键词: 痰饮 王旭高 用药规律 数据分析 |
| DOI： |
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| Medication rule and diagnosis-treatment characteristics of Wang Xugao in treatment of phlegm retention：A study based on data mining |
| WEI Dongliang,WANG Zhongliang,SHE Chang |
| (Nanjing University of Chinese Medicine，Nanjing 210023，Jiangsu，China;Xuzhou Hospital of Traditional Chinese Medicine，Xuzhou 221000，Jiangsu，China) |
| Abstract: |
| Objective：To investigate the prescriptions and medications in the “Phlegm Retention” section of The Medical Records of Wang Xugao in Clinical Practice and the medication rule of Wang Xugao in the treatment of phlegm retention.Methods：SPSS 25.0 and SPSS Modeler 18 were used for the analysis of frequency，nature/taste/meridian entry，and types of traditional Chinese medicine (TCM) drugs，as well as cluster analysis，factor analysis，and association rule analysis.Results：A total of 55 prescriptions，involving 104 TCM drugs，were obtained，with a total frequency of use of 597 times，and there were 14 high-frequency drugs (with a frequency of ≥11 times)，i.e.，Poria cocos，Pinellia ternata，tangerine peel，Atractylodes macrocephala Koidz.，Radix Glycyrrhizae，dried ginger，Ramulus Cinnamomi，prepared Radix Rehmanniae，Radix Aconiti Lateralis Preparata，Semen Armeniacae Amarum，Schisandra chinensis，Panax ginseng，coltsfoot flower，and Alisma orientalis.Among these 104 drugs，96 were included and classified based on their function，involving 17 types of drugs，and the drugs with the highest frequency of use were tonifying drugs and phlegm-eliminating，cough-relieving，and asthma-relieving drugs.The statistical analysis of nature/taste/meridian entry showed that most drugs were warm in nature and had a bitter，sweet，or pungent taste，and they mainly entered the lung，spleen，kidney，and stomach meridians.The association rule analysis obtained 35 commonly used drug combinations，and the cluster analysis and the factor analysis of high-frequency drugs obtained 3 associated prescriptions and 5 common factors.Conclusion：In the syndrome differentiation-based treatment of phlegm retention，Wang Xugao applied the general principle of warming，emphasized the influence of the kidney on phlegm retention，especially deficiency phlegm，used the method of nourishing，and helped the kidney to absorb Qi，with varied prescriptions in clinical practice，which still has a certain reference value in modern clinical practice. |
| Key words: phlegm retention Wang Xugao medication rule data analysis |
