| 摘要: |
| 目的：观察健脾消癌方治疗结直肠癌Ⅳ期脾虚瘀毒证的临床疗效。方法：将60 例结直肠癌Ⅳ期脾虚瘀毒证患者随机分为治疗组与对照组，每组各30 例。对照组采用mFOLFOX6方案行全身化疗，治疗组在对照组基础上联合中药汤剂健脾消癌方口服治疗。比较2组治疗前后Karnofsky功能状态（KPS）评分、肿瘤标志物［血清癌胚抗原（CEA）、糖类抗原199（CA199）］水平、免疫功能指标水平及中医证候积分，评定中医证候疗效。结果：中医证候疗效总有效率治疗组为83.33%（25/30），对照组为60.00%（18/30），2组差异有统计学意义(P<0.05)；与治疗前比较，治疗后2组KPS评分均提高，CEA和CAl99水平、中医证候积分均降低，免疫功能相关指标水平均升高，且治疗组均优于对照组，差异均有统计学意义（P<0.05）。结论：基于扶正消积法拟定的健脾消癌方可有效提高结直肠癌Ⅳ期脾虚瘀毒证患者的生活质量及免疫功能，并改善患者中医临床症状，降低肿瘤标志物水平，具有较好的推广价值。 |
| 关键词: 结直肠癌 Ⅳ期 脾虚瘀毒证 健脾消癌方 扶正消积 |
| DOI： |
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| Clinical effect of Jianpi Xiaoai prescription in treatment of stage IV advanced colorectal cancer with syndrome of spleen deficiency and stasis toxin：An analysis of 30 cases |
| ZHAO Ye,JIANG Yilan,WU Hongyu |
| (The Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Jianpi Xiaoai prescription in the treatment of stage IV advanced colorectal cancer with syndrome of spleen deficiency and stasis toxin.Methods：A total of 60 patients with stage IV advanced colorectal cancer with spleen deficiency and stasis toxin were randomly divided into treatment group and control group，with 30 patients in each group.The patients in the control group received systemic chemotherapy with the mFOLFOX6 regimen，and those in the treatment group received oral administration of the traditional Chinese medicine (TCM) decoction Jianpi Xiaoai prescription in addition to the treatment in the control group.The two groups were compared in terms of Karnofsky Performance Scale (KPS) score，tumor markers ［serum carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199)］，immune function parameters，and TCM syndrome score，and the treatment outcome of TCM syndrome was evaluated.Results：There was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group ［83.33% (25/30) vs 60.00% (18/30)，P<0.05］.After treatment，both groups had a significant increase in KPS score，significant reductions in CEA，CA199，and TCM syndrome，and significant increases in immune function parameters，and the treatment group had significantly better indicators than the control group (P<0.05).Conclusion：In the treatment of patients with stage IV advanced colorectal cancer with spleen deficiency and stasis toxin，Jianpi Xiaoai prescription developed based on the method of strengthening vital Qi and removing food retention can effectively improve quality of life and immune function，alleviate TCM clinical symptoms，and reduce the levels of tumor markers，and therefore，it holds promise for clinical application. |
| Key words: colorectal cancer stage IV syndrome of spleen deficiency and stasis toxin Jianpi Xiaoai prescription strengthening vital Qi and removing food retention |
