| 摘要: |
| 目的：观察益气养阴汤辅助培美曲塞联合顺铂（PP）方案对中晚期肺腺癌气阴两虚证患者的临床疗效。方法：将60 例中晚期肺腺癌气阴两虚证患者随机分为治疗组和对照组，每组各30 例。对照组予以PP方案治疗，治疗组在对照组基础上加用益气养阴汤治疗，2组均治疗4个疗程。比较2组治疗前后的肿瘤标志物［癌胚抗原（CEA）、糖类抗原125（CA125）］、中医证候评分、Karnofsky功能状态评分（KPS）、癌因性疲乏量表（CFS）各维度得分情况及治疗后2组实体瘤近期疗效、药物毒副作用的发生情况。结果:疾病控制率治疗组为93.33%（28/30），对照组为73.33%（22/30），2组比较，差异有统计学意义（P<0.05）；2组CEA和CA125水平、中医证候评分和CFS评分均较治疗前下降，且治疗组低于对照组（均P<0.05）；2组KPS评分均较治疗前提高，且治疗组高于对照组（P<0.05）；治疗4个疗程后，治疗组在治疗过程中毒副作用的发生率较对照组低，但差异无统计学意义（P>0.05）。结论：益气养阴汤辅助PP化疗方案可以降低中晚期肺腺癌气阴两虚证患者CEA和CA125水平，在一定程度上缓解患者的临床不适症状，改善癌因性疲乏，提高生活质量，增效且不会增加药物的毒副作用。 |
| 关键词: 肺腺癌 气阴两虚证 益气养阴汤 培美曲塞 顺铂 |
| DOI： |
|
|
| Clinical effect of Yiqi Yangyin decoction in assisting pemetrexed-cisplatin regimen for advanced lung adenocarcinoma with deficiency of both Qi and Yin：An analysis of 30 cases |
| YANG Jinfeng,LIANG Hui,DING Meiqian |
| (Anhui University of Chinese Medicine，Hefei 230012，Anhui，China;Lu’an Hospital of Traditional Chinese Medicine，Lu’an 237006，Anhui，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Yiqi Yangyin decoction in assisting the pemetrexed-cisplatin (PP) regimen for advanced lung adenocarcinoma with deficiency of both Qi and Yin.Methods：A total of 60 patients with advanced lung adenocarcinoma with deficiency of both Qi and Yin were randomly divided into treatment group and control group，with 30 patients in each group.The patients in the control group were given the PP regimen，while those in the treatment group were given Yiqi Yangyin decoction combined with the PP regimen alone；both groups were treated for 4 courses.The two groups were compared in terms of tumor markers ［carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125)］，traditional Chinese medicine (TCM) syndrome score，Karnofsky Performance Scale (KPS) score，and scores of each dimension of Cancer-related Fatigue Scale (CFS) before and after treatment，as well as short-term response of solid tumors and toxic and side effects of drugs.Results：There was a significant difference in disease control rate between the treatment group and the control group ［93.33% (28/30) vs 73.33% (22/30)，P<0.05］.After treatment，both groups had significant reductions in the levels of CEA and CA125，TCM syndrome score，and CFS score，and the treatment group had significantly lower values than the control group (P<0.05).After treatment，both groups had a significant increase in KPS score，and the treatment group had a significantly higher KPS score than the control group (P<0.05).After 4 courses of treatment，the treatment group had a lower incidence rate of toxic and side effects than the control group during treatment (P>0.05).Conclusion：In assisting the PP regimen for patients with advanced lung adenocarcinoma with deficiency of both Qi and Yin，Yiqi Yangyin decoction can reduce the levels of CEA and CA125，alleviate clinical discomforts to a certain degree，improve cancer-related fatigue and quality of life，and enhance the efficacy of drugs without increasing toxic and side effects. |
| Key words: lung adenocarcinoma deficiency of both Qi and Yin Yiqi Yangyin decoction pemetrexed cisplatin |
