| 摘要: |
| 目的：基于数据挖掘分析《重订古今名医临证金鉴·不孕卷》中不孕症的用药规律。方法：遴选并整理《重订古今名医临证金鉴·不孕卷》中治疗不孕症的有效经验方，对药物进行频数分析，采用SPSS Modeler 18.0统计软件进行关联规则分析，采用SPSS 28.0软件进行因子分析、聚类分析。结果：共收录59位古今名医治疗不孕症的方剂222首，中药238味，总用药频次为2511次，排前5位的中药依次为当归、白芍、川芎、香附、熟地黄。排前5位的功效种类依次为补虚药、活血化瘀药、理气药、清热药及利水渗湿药。中药药性以温为主，其次为平、寒性；药味以甘为主，其次为辛、苦味；归经以肝、脾、肾、心经为主。关联规则分析出高频关联药对16条，中药因子分析出6个公因子，聚类分析出5个聚类方。结论：《重订古今名医临证金鉴·不孕卷》所载历代医家治疗不孕症多以活血化瘀、补肾养血、疏肝行气、燥湿化痰为法，尤其重视从血论治，常以四物汤为基础方，为后世医家治疗不孕症提供了借鉴。 |
| 关键词: 不孕症 《重订古今名医临证金鉴·不孕卷》 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of infertility in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors：Volume of Infertility：An analysis based on data mining |
| ZHONG Zhiling,ZENG Jing,TAN Zhenyu |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of infertility in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors：Volume of Infertility based on data mining.Methods：Effective experienced prescriptions for the treatment of infertility were selected from Revised Clinical Practice Experience of Famous Ancient and Modern Doctors：Volume of Infertility，and drug frequency was analyzed.SPSS Modeler 18.0 was used for association rule analysis，and SPSS 28.0 was used for factor analysis and cluster analysis.Results：A total of 222 prescriptions used by 59 famous ancient and modern doctors for the treatment of infertility were collected，involving 238 traditional Chinese medicine (TCM) drugs.Total drug frequency was 2511 times，and the top 5 TCM drugs were Angelica sinensis，Radix Paeoniae Alba，Rhizoma Chuanxiong，Rhizoma Cyperi，and prepared Radix Rehmanniae.The top 5 types of TCM drugs in terms of function were deficiency-tonifying drugs，blood-activating and stasis-resolving drugs，Qi-regulating drugs，heat-clearing drugs，and diuresis-inducing and dampness-draining drugs.TCM drugs with a warm nature accounted for the highest proportion，followed by those with a neutral or cold nature；drugs with a sweet taste accounted for the highest proportion，followed by those with a pungent or bitter taste；most drugs entered the liver，spleen，kidney，and heart meridians.The association rule analysis obtained 16 high-frequency drug combinations，the TCM factor analysis obtained 6 common factors，and the cluster analysis obtained 5 cluster prescriptions.Conclusion：The famous ancient and modern doctors recorded in Revised Clinical Practice Experience of Famous Ancient and Modern Doctors：Volume of Infertility mainly used the methods of blood-activating and stasis-resolving therapy，kidney-tonifying and blood-nourishing therapy，liver -soothing and Qi-moving therapy，and dampness-drying and phlegm-eliminating therapy for the treatment of infertility，especially by solving disorders of the blood system，and Siwu Decoction was often used as the basic prescription，which provides a reference for the treatment of infertility by doctors of later generations. |
| Key words: infertility Revised Clinical Practice Experience of Famous Ancient and Modern Doctors：Volume of Infertility data mining medication rule |
