| 摘要: |
| 目的：探讨古今中医药治疗类风湿性关节炎（RA）的用药规律，为RA临床组方用药提供依据及参考。方法：古方以《中医方剂大辞典》为检索数据库，今方以中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP）为检索数据库，筛选建库至2020年10月31日治疗RA的方剂，采用频次统计、聚类分析及基于Aprior算法的关联规则分析比较古今用药的特点及规律。结果：古今治疗RA使用频次排前10位的药物中，均有当归、防风、牛膝、羌活、独活、甘草。四气以温性药物应用较多，五味以辛、苦、甘味为主，归经以肝、脾、肾、肺经较多，功效方面以祛风湿、清热、补虚、活血化瘀药出现频次最多。对24味中药进行系统聚类分析，古方得到5个新方，今方得到3个新方。关联规则结果显示，古方共筛选出24个关联规则，其中二阶关联规则15个，三阶关联规则9个；今方共筛选出20个关联规则，其中二阶关联规则10个，三阶关联规则10个。结论：古今治疗RA核心用药基本一致，体现了中医治则治法的精髓。 |
| 关键词: 类风湿性关节炎 古方 今方 用药规律 |
| DOI： |
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| Medication rule of ancient and modern traditional Chinese medicine therapies in treatment of rheumatoid arthritis：A study based on data mining |
| YANG Ping,QU Jilan |
| (Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，Gansu，China;Gansu Provincial Hospital，Lanzhou 730013，Gansu，China) |
| Abstract: |
| Objective：To investigate the medication rule of ancient and modern traditional Chinese medicine therapies in the treatment of rheumatoid arthritis (RA)，and to provide a reference for clinical prescription and medication for RA.Methods：Dictionary of Traditional Chinese Medicine Prescriptions was searched for related ancient prescriptions，and CNKI，Wanfang Data，and VIP databases were search for modern prescriptions for the treatment of RA published up to October 31，2020.Frequency statistics，cluster analysis，and association rule analysis based on Aprior algorithm were used to analyze and compare the medication features and rules of ancient and modern prescriptions.Results：Angelica sinensis，Saposhnikovia divaricata，Achyranthis Bidentatae Radix，notopterygium root，Angelica pubescens，and Radix Glycyrrhizae were among the top 10 drugs in terms of frequency of use for the treatment of RA in both ancient and modern prescriptions.Most drugs were warm in nature and had a pungent，bitter or sweet taste，and most drugs entered the liver，spleen，kidney，and lung meridians.As for function，wind-damp-dispelling，heat-clearing，deficiency-tonifying，and blood-activating and stasis-resolving drugs had the highest frequency.Hierarchical cluster analysis of 24 TCM drugs obtained 5 new ancient prescriptions and 3 new modern prescriptions.Association rule analysis showed that 24 association rules were screened out for ancient prescriptions，with 15 second-order association rules and 9 third-order association rules，and 20 association rules were screened out for modern prescriptions，with 10 second-order association rules and 10 third-order association rules.Conclusion：Core drugs are basically consistent between ancient and modern prescriptions for the treatment of RA，which reflects the essence of the principle and method of treatment in traditional Chinese medicine. |
| Key words: rheumatoid arthritis ancient prescription modern prescription medication rule |
