| 摘要: |
| 目的：探讨鼻敏宁颗粒对变应性鼻炎（AR）大鼠行为以及鼻黏膜组织形态的影响。方法：将60只大鼠随机分成6组，即空白对照组，模型组，辛芩颗粒对照组（阳性对照组），鼻敏宁颗粒高、中、低剂量组（简称为高、中、低剂量组），每组各10只。造模成功后于局部激发第5次当日开始干预，高、中、低剂量组分别灌服2 、1、0.5 g/kg的鼻敏宁颗粒，阳性对照组给予5 g/kg的辛芩颗粒，空白对照组与模型组灌服同等容积的0.9%氯化钠注射液，连续干预7 d。观察大鼠行为以及鼻黏膜组织病理学变化。结果：干预后高、中、低剂量组与阳性对照组均能降低大鼠的分泌量、喷嚏及搔鼻评分，与干预前比较，差异均有统计学意义（P＜0.05）；干预后高剂量组与低、中剂量组及阳性对照组比较，差异均有统计学意义（P＜0.05）。组织病理学结果显示，鼻敏宁颗粒各剂量组黏膜炎症浸润明显比模型组轻。结论：鼻敏宁颗粒可改善AR大鼠模型的过敏性行为，降低AR大鼠模型鼻黏膜的炎性反应。 |
| 关键词: 变应性鼻炎 过敏性行为 组织形态 鼻敏宁颗粒 大鼠 实验研究 |
| DOI： |
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| Effect of Biminning granules on behavior and nasal mucosal histomorphology in rats with allergic rhinitis |
| PENG Bo,LING Yanjun |
| (The Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the effect of Biminning granules on behavior and nasal mucosal histomorphology in rats with allergic rhinitis (AR).Methods：A total of 60 rats were randomly divided into blank control group，model group，Xinqin granules control group (positive control group)，and high-，middle-，and low-dose Biminning granules groups (high-，middle-，and low-dose groups，respectively)，with 10 rats in each group.After successful modeling，the drugs were given on the day of local challenge for the fifth time；the rats in the high-，middle-，and low-dose groups were give Biminning granules by gavage at doses of 2，1，and 0.5 g/kg，respectively，those in the positive control group were given Xinqin granules at a dose of 5 g/kg，and those in the blank control group and the model group were given an equal volume of 0.9% sodium chloride injection，for 7 consecutive days.The changes in behavior and nasal mucosal histomorphology were evaluated.Results：The high-，middle-，and low-dose groups and the positive control group had significant reductions in secretion amount，sneeze，and nose-scratching score after administration (P＜0.05)，and there were significant differences in these indices between the high-dose group and the low-dose/middle-dose/positive control groups after administration (P＜0.05).Histopathological results showed that the high-，middle-，and low-dose groups had a lower degree of inflammatory cell infiltration in mucosa than the model group.Conclusion：Biminning granules can improve allergic behavior and reduce inflammatory response of nasal mucosa in a rat model of AR. |
| Key words: allergic rhinitis allergic behavior histomorphology Biminning granules rat experimental study |
