| 摘要: |
| 目的：优化化瘀骨合片的提取工艺条件。方法：以牡荆苷含量、芍药苷含量和固形物质量为评价指标，在单因素试验的基础上设计正交试验，考察料液比、提取时间、提取次数对提取工艺的影响，优化提取工艺条件。结果：最佳工艺条件为全方药材加水提取3次，每次加12倍量水提取2h，该条件下牡荆苷的提取率为89.81%，芍药苷的提取率为86.08%。结论：优选的提取工艺稳定，指标成分的提取率高，工艺合理可行。 |
| 关键词: 化瘀骨合片 提取工艺 正交试验 主成分分析 |
| DOI： |
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| Optimization of the extraction process for Huayu Guhe tablets |
| LI Jiehuan,ZHANG Jianjun,CHEN Xueting |
| (Guangdong Second Provincial Traditional Chinese Medicine Hospital (Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology)/Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Research and Development，Guangzhou 510095，Guangdong，China) |
| Abstract: |
| Objective：To optimize the extraction process forHuayu Guhe tablets.Methods：With the content of vitexin，the content of paeoniflorin，and solid content mass as assessment indices，an orthogonal test was designed on the basis of single-factor experiment to investigate the influence of solid-liquid ratio，extraction time，and times of extraction on extraction process and optimize the conditions of the extraction process.Results：The optimal conditions of extraction were as follows：the medicinal materials of the whole prescriptionwere mixed with water (12 times)，and extraction was performed 3 times，for 2 hours each.The extraction rates of vitexin and paeoniflorin were 89.81%and 86.08%，respectively，under such conditions.Conclusion：The optimized extraction process is stable and can achieve a high extraction rate of index components，and therefore，this process is reasonable and feasible. |
| Key words: Huayu Guhe tablets extraction process orthogonal test principal component analysis |
