| 摘要: |
| 目的：研究川芎对D-半乳糖衰老模型小鼠抗衰老的作用机制。方法：将50只小鼠随机分为正常对照组10只和造模组40只,采用颈背部皮下注射D-半乳糖溶液的方法建立小鼠衰老模型,再将其分为衰老模型组及川芎低、中、高剂量组,每组各10只。药物干预50 d后检测小鼠脑组织中的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）、单胺氧化酶（MAO）。结果：与正常对照组比较,衰老模型组脑组织中SOD、GSH-Px含量降低,MDA、MAO含量升高,差异均有统计学意义（P＜0.05）；与衰老模型组比较,川芎低、中、高剂量组SOD、GSH-Px含量增加,MDA、MAO含量降低,差异均有统计学意义（P＜0.05）。结论：川芎可增加脑组织中SOD、GSH-Px含量,降低MDA、MAO含量,具有良好的延缓衰老的作用。 |
| 关键词: 衰老 川芎 D-半乳糖 作用机制 实验研究 |
| DOI： |
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| Anti-senescence mechanism of Rhizoma Ligustici Chuanxiong in a mouse model of senescence induced by D-galactose |
| LIU Ying,LI Hua,LIU Wanghua |
| (Hunan University of Chinese Medicine,Changsha 410208,Hunan,China) |
| Abstract: |
| Objective：To investigate the anti-senescence mechanism of Rhizoma Ligustici Chuanxiong in a mouse model of senescence induced by D-galactose.Methods：A total of 50 mice were randomly divided into normal control group with 10 mice and modeling group with 40 mice.A mouse model of senescence was established by subcutaneous injection of D-galactose solution at the neck and back,and then the modeling group was further divided into senescence model group and low-,middle-,and high-dose Rhizoma Ligustici Chuanxiong groups,with 10 mice in each group.The levels of superoxide dismutase (SOD),glutathione peroxidase (GSH-Px),malondialdehyde (MDA),and monoamine oxidase (MAO) in brain tissue were measured after 50 days of drug intervention.Results：Compared with the normal control group,the senescence model group had significant reductions in SOD and GSH-Px and significant increases in MDA and MAO in brain tissue (P<0.05).Compared with the senescence model group,the low-,middle-,and high-dose Rhizoma Ligustici Chuanxiong groups had significant increases in SOD and GSH-Px and significant reductions in MDA and MAO in brain tissue (P<0.05).Conclusion：Rhizoma Ligustici Chuanxiong can increase the levels of SOD and GSH-Px and reduce the levels of MDA and MAO in brain tissue and thus has a good effect in delaying senescence. |
| Key words: senescence Rhizoma Ligustici Chuanxiong D-galactose mechanism of action experimental study |
