| 摘要: |
| 目的：探讨黄精复方治疗气阴两虚型2型糖尿病的临床疗效。方法：将气阴两虚型2型糖尿病患者64 例随机分为治疗组和对照组,每组各32 例。所有患者均采取饮食、运动等生活方式干预,对照组口服二甲双胍片治疗,治疗组在对照组基础上加用黄精复方治疗,疗程均为12周。观察2组综合疗效及治疗前后中医证候积分、体质量指数（BMI）、空腹血糖（FBG）、餐后2 h血糖（2hPG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）的变化,记录2组不良反应。结果：总有效率治疗组为87.50%（28/32）,高于对照组的59.37%（19/32）,差异有统计学意义（P＜0.05）。2组中医证候积分、BMI、FBG、2hPG、HbA1c、FINS、HOMA-IR、TC、TG、LDL-C、HDL-C治疗前后组内比较及治疗后组间比较,差异均有统计学意义（均P＜0.05）。结论：黄精复方治疗气阴两虚型2型糖尿病可以缓解患者的中医证候,降低血糖、血脂,改善胰岛功能,从而提高临床疗效。 |
| 关键词: 2型糖尿病 气阴两虚证 中西医结合疗法 黄精复方 二甲双胍 |
| DOI： |
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| Clinical effect of compound Polygonatum sibiricum prescription in treatment of type 2 diabetes with deficiency of both Qi and Yin：An analysis of 32 cases |
| GONG Guangming,ZHANG Yuan,YUAN Haipo |
| (The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan,China) |
| Abstract: |
| Objective:To investigate the clinical effect of compound Polygonatum sibiricum prescription in the treatment of type 2 diabetes with deficiency of both Qi and Yin.Methods：A total of 64 patients with type 2 diabetes with deficiency of both Qi and Yin were randomly divided into treatment group and control group,with 32 patients in each group.All patients were given lifestyle intervention including diet and exercise;the patients in the control group were given oral metformin tablets,and those in the treatment group were given compound Polygonatum sibiricum prescription in addition to the treatment in the control group;the course of treatment was 12 weeks for both groups.The two groups were compared in terms of overall response and changes in traditional Chinese medicine (TCM) syndrome score,body mass index (BMI),fasting blood glucose (FBG),2-hour postprandial glucose (2hPG),hemoglobin A1c (HbA1c),fasting insulin (FINS),homeostasis model assessment of insulin resistance (HOMA-IR),total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),and low-density lipoprotein cholesterol (LDL-C) after treatment,and adverse reactions were recorded for both groups.Results：The treatment group had a significantly higher overall response rate than the control group ［87.50% (28/32) vs 59.37% (19/32),P＜0.05］.Both groups had significant changes in TCM syndrome score,BMI,FBG,2hPG,HbA1c,FINS,HOMA-IR,TC,TG,LDL-C,and HDL-C after treatment,and there were significant differences in these indices between the two groups after treatment (all P＜0.05).Conclusion：In the treatment of type 2 diabetes with deficiency of both Qi and Yin,compound Polygonatum sibiricum prescription can alleviate TCM syndrome,reduce blood glucose,regulate lipids,improve pancreatic islet function,and thus improve clinical outcome. |
| Key words: type 2 diabetes deficiency of both Qi and Yin integrated traditional Chinese and Western medicine therapy compound Polygonatum sibiricum prescription metformin |
