| 摘要: |
| 目的：观察扶肝祛瘀丸对肝胆湿热兼血瘀型肝纤维化患者的临床疗效及其对血清自然杀伤（NK）细胞的影响,并探讨其安全性。方法：将100 例肝胆湿热兼血瘀型肝纤维化患者随机分为治疗组和对照组,每组各50 例。2组均予基础治疗,治疗组加用扶肝祛瘀丸治疗,对照组加用安慰丸剂治疗,疗程均为12周。观察2组治疗前后中医证候、肝肾功能指标［谷氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBil）、肌酐（Cr）］、血常规［白细胞(WBC)、红细胞（RBC）］、肝纤维化指标［透明质酸（HA）、Ⅲ前胶原N端肽（PⅢNP）、Ⅳ型胶原（Ⅳ-C）］及AST与血小板比值（APRI）、纤维蛋白原-4（FIB4）指数、肝脏硬度值、NK细胞的变化,比较2组综合疗效。结果：总有效率治疗组为90.0%（45/50）,对照组为74.0%（37/50）,组间比较,差异具有统计学意义（P＜0.05）。治疗后,2组ALT、HA、PⅢNP、IV-C、肝脏硬度值、NK细胞均较治疗前有所改善,组内及组间比较差异均有统计学意义（P＜0.05或P＜0.01）,其余指标治疗后差异无统计学意义（P＞0.05）。结论：扶肝祛瘀丸治疗肝胆湿热兼血瘀型肝纤维化临床疗效显著,能明显降低患者血清肝纤维化指标,提高血清NK细胞水平,改善机体免疫功能,且安全有效。 |
| 关键词: 肝纤维化 肝胆湿热兼血瘀证 扶肝祛瘀丸 NK细胞 |
| DOI： |
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| Clinical effect of Fugan Quyu pills in treatment of liver fibrosis with damp-heat in the liver and gallbladder and blood stasis：An analysis of 50 cases |
| WEI Dong,XIONG Yanchun,LI Wensheng |
| (Guangdong Second Provincial Traditional Chinese Medicine Hospital,Guangzhou 510095,Guangdong,China;Hospital of Guangzhou Bureau of Drug Rehabilitation,Guangzhou 510435,Guangdong,China;Yanbu Community Health Service Center of Dali Town in Nanhai District,Foshan 526117,Guangdong,China) |
| Abstract: |
| Objective:To investigate the clinical effect and safety of Fugan Quyu pills in the treatment of patients with liver fibrosis with damp-heat in the liver and gallbladder and blood stasis and its effect on serum natural killer (NK) cells.Methods：A total of 100 patients with liver fibrosis with damp-heat in the liver and gallbladder and blood stasis were randomly divided into treatment group and control group,with 50 patients in each group.In addition to basic treatment,the patients in the treatment group were given Fugan Quyu pills,and those in the control group were given placebo;the course of treatment was 12 weeks for both groups.The two groups were observed in terms of traditional Chinese medicine syndrome,liver and renal function parameters ［alanine aminotransferase (ALT),aspartate aminotransferase,total bilirubin,and creatinine］,routine blood test results (white blood cell count and red blood cell count),liver fibrosis markers ［hyaluronic acid (HA),procollagen Ⅲ N-terminal peptide (PⅢNP),and type IV collagen (IV-C)］,aspartate aminotransferase-to-platelet ratio index,fibrosis-4 (FIB-4) index,liver stiffness,and NK cells before and after treatment,and overall response was compared between the two groups.Results：There was a significant difference in overall response rate between the treatment group and the control group ［90.0% (45/50) vs 74.0% (37/50),P＜0.05］.After treatment,both groups had significant improvements in ALT,HA,PⅢNP,IV-C,liver stiffness,and NK cells,and there were significant differences between the two groups (P＜0.05 or P＜0.01);no significant differences were observed for the other indices after treatment (P>0.05).Conclusion：Fugan Quyu pills have a marked clinical effect and good safety in the treatment of liver fibrosis with damp-heat in the liver and gallbladder and blood stasis and can significantly reduce serum liver fibrosis markers,increase serum NK cells,and improve immune function. |
| Key words: liver fibrosis damp-heat in the liver and gallbladder and blood stasis Fugan Quyu pills natural killer cell |
