| 摘要: |
| 目的：观察益心通络胶囊对不稳定型心绞痛患者经皮冠状动脉介入（PCI）术后再发的治疗效果。方法：将不稳定型心绞痛PCI术后再发患者80 例随机分为治疗组和对照组。对照组38例给予常规西药治疗，治疗组42例在对照组基础上加用益心通络胶囊治疗。比较2组心绞痛疗效、中医证候疗效、硝酸酯类停减率及治疗前后24 h心率变异性（HRV）指标、炎症因子水平的变化。结果：治疗后，治疗组心绞痛疗效、中医证候疗效总有效率及硝酸酯类停减率分别为83.33%（35/42）、85.71%（36/42）与73.81%（31/42），明显高于对照组的55.27%（21/38）、60.53%（23/38）与50.00%（19/38），组间比较，差异均有统计学意义（P＜0.05）；2组24h HRV指标及各项炎症因子水平治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.05）。结论：益心通络胶囊可降低不稳定型心绞痛PCI术后再发患者的炎症因子水平，提高HRV和硝酸酯类减停率，改善中医证候，提高心绞痛的治疗效果，值得临床借鉴。 |
| 关键词: 不稳定型心绞痛 PCI术后再发心绞痛 益心通络胶囊 心率变异性 炎症因子 |
| DOI： |
|
|
| Clinical effect of Yixin Tongluo capsules in treatment of patients with recurrent unstable angina after percutaneous coronary intervention：An analysis of 42 cases |
| MENG Xianliang |
| (Tai’an Hospital of Traditional Chinese Medicine，Tai’an 271000，Shandong，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Yixin Tongluo capsules in the treatment of patients with recurrent unstable angina after percutaneous coronary intervention (PCI).Methods：A total of 80 patients with recurrent unstable angina after PCI were randomly divided into treatment group and control group.The 38 patients in the control group were given conventional Western medicine treatment，and the 42 patients in the treatment group were given Yixin Tongluo capsules in addition to the treatment in the control group.The two groups were compared in terms of treatment outcome of angina pectoris，treatment outcome of traditional Chinese medicine (TCM) syndrome，withdrawal or reduction rate of nitrates，and changes in 24-hour heart rate variability (HRV) and inflammatory factors after treatment.Results：Compared with the control group after treatment，the treatment group had significantly higher response rate of angina pectoris ［83.33% (35/42) vs 55.27% (21/38)，P＜0.05］，overall response rate of TCM syndrome ［85.71% (36/42) vs 60.53% (23/38)，P＜0.05］，and withdrawal or reduction rate of nitrates［73.81% (31/42) vs 50.00% (19/38)，P＜0.05］.After treatment，both groups had significant changes in 24-hour HRV and inflammatory factors，and there were significant differences in these indices between the two groups (P＜0.05).Conclusion：In patients with recurrent unstable angina after PCI，Yixin Tongluo capsules can reduce inflammatory factors and increase HRV and withdrawal or reduction rate of nitrates，improve TCM syndrome,improve treatment outcome of angina pectoris，and therefore，it holds promise for clinical application. |
| Key words: unstable angina recurrent unstable angina after percutaneous coronary intervention Yixin Tongluo capsule heart rate variability inflammatory factor |
