| 摘要: |
| 目的：考查郑氏熏洗药泡腾颗粒、软膏的镇痛效果，为其临床应用提供实验依据。方法：选取昆明小鼠160只，将每80只小鼠分为8组，空白对照组，阳性对照组，郑氏熏洗泡腾药颗粒高、中、低剂量组（分别简称为泡腾颗粒高、中、低剂量组），郑氏熏洗药软膏高、中、低剂量组（分别简称为软膏高、中、低剂量组），每组各10只。采用热板法和扭体法观察泡腾颗粒与软膏2种剂型对小鼠热刺激致痛反应及化学刺激致痛反应的影响，评价2种剂型的镇痛作用。结果：给药后，泡腾颗粒高剂量组30、60、120、240 min的痛阈值，中剂量组30、60、120 min的痛阈值均均增高，泡腾颗粒低剂量组30 min的痛阈值增高；软膏高、中剂量组30、60、120、240、360 min的痛阈值增高，软膏低剂量组30、60、120 min的痛阈值均增高，与空白对照组比较，差异均有统计学意义（P＜0.05，P<0.01）。软膏高剂量组扭体反应的潜伏期较空白对照组升高（P＜0.05）；泡腾颗粒高剂量组，软膏高、中剂量组小鼠扭体次数较空白对照组减少，差异有统计学意义（P＜0.05）。结论：郑氏熏洗药泡腾颗粒、软膏2种剂型均具有显著的镇痛作用，软膏较泡腾颗粒镇痛作用稍强。 |
| 关键词: 郑氏熏洗药 泡腾颗粒 软膏 镇痛 比较药理学 实验研究 |
| DOI： |
|
|
| Analgesic effect of the effervescent granules versus the ointment of Zheng’s fumigation-washing drug |
| CHENG Zhenzhen,JU Shaohua,WANG Mingjian |
| (Affiliated Sport Hospital of Chengdu Sport University，Chengdu 610041，Sichuan，China) |
| Abstract: |
| Objective：To investigate the analgesic effect of the effervescent granules and the ointment of Zheng’s fumigation-washing drug，and to provide an experimental basis for its clinical application.Methods：A total of 160 KM mice were selected and divided into two groups，with 80 mice in each group，and each group was further divided into blank control group，positive control group，high-，middle-，and low-dose effervescent granules groups，and high-，middle-，and low-dose ointment groups，with 10 mice in each group.The hot plate method and the writhing method were used to observe the effect of the effervescent granules and the ointment on pain reaction caused by thermal stimulation and chemical stimulation，and the analgesic effect of the two dosage forms were evaluated.Results：After administration，the high-dose effervescent granules group had increases in the pain thresholds at 30，60，120，and 240 minutes，the middle-dose effervescent granules group had increases in the pain thresholds at 30，60，and 120 minutes，and the low-dose effervescent granules group had an increase in the pain threshold at 30 minutes；the high- and middle-dose ointment groups had increases in the pain thresholds at 30，60，120，240，and 360 minutes，and the low-dose ointment group had increases in the pain thresholds at 30，60，and 120 minutes；there were significant differences between these groups and the blank control group (P＜0.05 or P＜0.01).The high-dose ointment group had a significant increase in the latency period of writhing response (P＜0.05)，and compared with the blank control group，the high-dose effervescent granules group and high- and middle-dose ointment groups had a significant reduction in the number of writhing times (P＜0.05).Conclusion：Both effervescent granules and ointment of Zheng’s fumigation-washing drug have a marked analgesic effect，and the ointment has a slightly better analgesic effect than the effervescent granules. |
| Key words: Zheng’s fumigation-washing drug effervescent granules ointment analgesic effect comparative pharmacology experimental study |
