| 摘要: |
| 目的：观察化浊解毒汤治疗慢性萎缩性胃炎（CAG）的临床疗效及对患者生存质量的影响。方法：将80 例慢性萎缩性胃炎患者随机分为治疗组和对照组，每组各40 例。治疗组予化浊解毒汤治疗，对照组予胃复春片治疗，2组疗程均为6个月。观察2组治疗前后中医证候积分、病理组织学分级，评定中医证候疗效及病理组织学疗效；采用健康状况调查简表（SF-36）对患者治疗前后生存质量进行评价。结果：中医证候疗效、病理组织学疗效治疗组分别为92.5%（37/40）、80.0%（32/40），对照组分别为77.5%（31/40）、55.0%（22/40），2组比较，差异均有统计学意义（P＜0.05）。治疗组在生存质量中躯体疼痛（BP）、社交功能(SF)、情感职能（RE）3个方面的评分优于对照组，差异有统计学意义（P＜0.05）。结论：化浊解毒中药治疗CAG临床疗效明显，并可提高患者生存质量。 |
| 关键词: 慢性萎缩性胃炎 中医药疗法 化浊解毒汤 生存质量 |
| DOI： |
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| Clinical effect of Huazhuo Jiedu decoction in treatment of chronic atrophic gastritis：An analysis of 40 cases |
| YANG Qian,KANG Xin,LIU Jianping |
| (Hebei Provincial Hospital of Traditional Chinese Medicine，Shijiazhuang 050011，Hebei，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Huazhuo Jiedu decoction in the treatment of chronic atrophic gastritis (CAG) and its effect on patients’ quality of life.Methods：A total of 80 patients with CAG were randomly divided into treatment group and control group，with 40 patients in each group.The patients in the treatment group were given Huazhuo Jiedu decoction，and those in the control group were given Weifuchun tablets.The course of treatment was 6 months for both groups.Traditional Chinese medicine (TCM) syndrome score and histopathological grade were observed before and after treatment to evaluate the outcome of TCM syndrome and histopathological outcome，and 36-Item Short-Form Health Survey was used to evaluate quality of life before and after treatment.Results：There were significant differences between the treatment group and the control group in the outcome of TCM syndrome [92.5% (37/40) vs 77.5% (31/40)，P＜0.05] and histopathological outcome [80.0% (32/40) vs 55.0% (22/40)，P＜0.05].As for quality of life，the treatment group had significantly better scores of bodily pain，social function，and role emotional than the control group (P＜0.05).Conclusion：TCM therapy with Huazhuo Jiedu decoction has a marked clinical effect in the treatment of CAG and can improve patients’ quality of life. |
| Key words: chronic atrophic gastritis traditional Chinese medicine treatment Huazhuo Jiedu decoction quality of life |
