| 摘要: |
| 目的：探讨糖尿病患者体质、炎症因子白细胞介素-6（IL-6）、C反应蛋白（CRP）水平与足溃疡预后的关系，为糖尿病足溃疡（DFU）的防治提供新思路。方法：收集71例住院的DFU患者，采用《中医体质分类与判定》评定患者体质，测定炎症因子IL-6、CRP水平及伤口情况（wagner分级、感染程度）。观察不同体质DFU患者伤口愈合时间（是否超过4周）。分析主要体质的代谢指标、伤口情况及炎症因子IL-6、CRP水平。结果：血瘀质和湿热质是DFU难愈伤口的常见体质，痰湿质伤口相对易愈。3种体质伤口wagner分级比较无统计学差异（P＞0.05），感染程度比较有统计学差异（P<0.05）。血瘀质、湿热质难愈伤口感染程度较痰湿质易愈伤口重，炎症因子IL-6、CRP水平均比痰湿质易愈伤口高。血清IL-6、CRP与伤口愈合成负相关（P>0.05），与感染程度成正相关（P<0.05），踝肱指数与感染程度成负相关（P<0.01）。结论：血瘀质、湿热质糖尿病患者伤口较难愈合，其伤口愈合困难可能与易感染、机体氧化应激加重等因素导致炎症因子水平升高有关。 |
| 关键词: 糖尿病足溃疡 体质 炎症因子 |
| DOI： |
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| Association of body constitution and inflammatory factors with prognosis of foot ulcer in patients with diabetes |
| TAN Yanmei,JIN Rongchen |
| (The Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China;Hunan University of Chinese Medicine，Changsha 410208，Hunan，China) |
| Abstract: |
| Objective：To investigate body constitution and levels of the inflammatory factors interleukin-6（IL-6）and C-reactive protein（CRP）in patients with diabetes and their association with the prognosis of diabetic foot ulcer，and to provide new thoughts for the prevention and treatment of diabetie foot alcer（DFU）.Methods：A total of 71 hospitalized patients with DFU were enrolled，and Classification and Determination of Constitution in TCM was used to evaluate body constitution.The levels of the inflammatory factors IL-6 and CRP were measured，and the conditions of the wound were evaluated in terms of Wagner classification and degree of infection.Whether wound healing time of DFU was longer than 4 weeks was observed for patients with different body constitutions.Metabolic markers，wound conditions，and levels of IL-6 and CRP in major body constitutions were analyzed.Results：DFU wounds were hard to heal in the patients with blood-stasis or damp-heat constitution，and those in the patients with phlegm-dampness constitution were relatively easy to heal.There was no significant difference in Wagner classification of wound between the patients with three body constitutions（P>0.05），while there was a significant difference in the degree of infection（P<0.05）.Compared with those with phlegm-dampness constitution，the patients with blood-stasis or damp-heat constitution had significantly higher degree of wound infection and levels of IL-6 and CRP.Serum IL-6 and CRP were negatively correlated with wound healing time（P>0.05）and positively correlated with the degree of infection（P<0.05），and ankle-brachial index was negatively correlated with the degree of infection（P<0.01）.Conclusion：Diabetic patients with blood-stasis or damp-heat constitution have difficulties in wound healing of DFU，which might be associated with the increases in inflammatory factors due to infection and aggravation of oxidative stress. |
| Key words: diabetic foot ulcer body constitution inflammatory factor |
