| 摘要: |
| 目的：探讨百令胶囊对于糖尿病肾病模型大鼠各种炎症因子表达的影响。方法：将SD大鼠随机分为正常组、模型组、治疗组和对照组，对除正常组外的其余组大鼠建立糖尿病肾病模型大鼠，灌胃给药8周后观察大鼠体质量/肾比重、血糖、IL-6、尿微量白蛋白、TGF-β、MCP-1等变化，HE染色检测肾组织病理变化。结果：与模型组相比，治疗组能降低模型大鼠肾指数、血糖，减少尿微量白蛋白，降低IL-6、MCP-1水平，差异均有统计学意义（P<0.05或P<0.01）；HE染色显示，与模型组相比，治疗组与对照组肾脏病变均有减轻趋势，治疗组较为明显。结论：百令胶囊在降低血糖、减少蛋白尿、减轻血清炎症因子表达等方面具有良好的作用，能够改善病理组织，下调MCP-1的表达，延缓糖尿病肾病进展。 |
| 关键词: 糖尿病肾病 百令胶囊 炎症因子 TGF-β MCP-1 实验研究 |
| DOI： |
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| Effect of Bailing capsules on the expression of inflammatory factors in rats with diabetic nephropathy：An experimental study |
| YU Zhong-xian,JIN Zhong-da,ZHANG Wen-jun |
| (Department of Traditional Chinese Medicine，Changshu First People’s Hospital & Changshu Hospital Affiliated to Soochow University，Changshu 215500，Jiangsu，China) |
| Abstract: |
| Objective：To investigate the effect of Bailing capsules on the expression of inflammatory factors in rats with diabetic nephropathy.Methods：Sprague-Dawley rats were randomly divided into normal group，model group，treatment group，and control group.All rats except those in the normal group were used to establish a model of diabetic nephropathy.After 8 weeks of administration by gavage，the changes in body weight/kidney weight ratio，blood glucose，interleukin-6（IL-6)，urinary microalbumin，transforming growth factor-β，and monocyte chemotactic protein 1（MCP-1) were measured，and HE staining was used to observe the pathological changes of the kidney.Results：Compared with the model group，the treatment group had significant reductions in kidney index，blood glucose，urinary microalbumin，IL-6，and MCP-1（P<0.05 or P<0.01).HE staining showed that compared with the model group，the treatment group and the control group had slight alleviation of renal lesions，and the treatment group had greater improvement than the control-group.Conclusion：Bailing capsules have a good effect in reducing blood glucose，proteinuria，and expression of inflammatory factors in serum and can improve pathological changes，downregulate the expression of MCP-1，and delay the progression of diabetic nephropathy. |
| Key words: diabetic nephropathy Bailing capsule inflammatory factor transforming growth factor-β monocyte chemotactic protein 1 experimental study |
