| 摘要: |
| 目的：观察驻景丸加减方联合中药熏蒸治疗干眼（dry eye disease，DED）的临床疗效。方法：将76例DED患者随机分为治疗组与对照组，每组各38例。对照组予以常规西药治疗，治疗组在对照组基础上加用驻景丸加减方联合中药熏蒸治疗，2组均连续治疗4周。于治疗前后观察2组主观症状积分及客观症状指标结果［（泪膜破裂时间（tear film break-up time，BUT）、泪液分泌试验（schirmer i test，SIT）结果、角膜上皮荧光染色（fluorescein staining，FS）积分］变化，并评价临床疗效。结果：总有效率治疗组为92.11%（35/38），对照组为73.68%（28/38），2组比较，差异有统计学意义（P<0.05）；2组主观症状积分及各客观症状指标结果治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.01或P<0.05）。结论：驻景丸加减方联合中药熏蒸可有效改善DED患者临床表现，且临床疗效优于单纯使用玻璃酸钠滴眼液。 |
| 关键词: 干眼 驻景丸加减方 中药熏蒸 临床疗效 中西医结合疗法 |
| DOI： |
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| Modified Zhujing pills combined with traditional Chinese medicine fumigation and steaming therapy in treatment of dry eye disease: An analysis of 38 cases |
| ZHOU Meng,WU Lilong |
| (Hunan University of Chinese Medicine, Changsha 410208, Hunan, China;Xiangtan Hospital of Traditional Chinese Medicine, Xiangtan 411100, Hunan, China;The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, Hunan, China) |
| Abstract: |
| Objective： To investigate the clinical effect of modified Zhujing pills combined with traditional Chinese medicine （TCM） fumigation and steaming therapy in the treatment of dry eye disease （DED）. Methods： A total of 76 patients with DED were randomly divided into treatment group and control group, with 38 patients in each group. The patients in the control group received conventional Western medicine treatment, while those in the treatment group received modified Zhujing pills combined with TCM fumigation and steaming therapy in addition to the treatment in the control group, and both groups were treated for 4 consecutive weeks. The two groups were observed in terms of the changes in subjective symptom scores and objective symptom indicators （tear film break-up time, Schirmer I test results, and fluorescein staining score） after treatment, and clinical outcome was assessed for both groups. Results： There was a significant difference in overall response rate between the treatment group and the control group ［92.11% （35/38） vs 73.68% （28/38）, P < 0.05］. Both groups had significant changes in subjective symptom scores and objective symptom indicators after treatment, and there were significant differences in these indicators between the two groups after treatment （P < 0.01 or P < 0.05）. Conclusion： Modified Zhujing pills combined with TCM fumigation and steaming therapy can effectively improve the clinical manifestations of patients with DED, with a better clinical effect than sodium hyaluronate eye drops alone. |
| Key words: dry eye disease Modified Zhujing pills traditional Chinese medicine fumigation and steaming therapy clinical effect integrated traditional Chinese and Western medicine therapy |
