| 摘要: |
| 目的：观察加味金水六君煎治疗慢性阻塞性肺疾病（chronic obstructive Pulmon-ary disease，COPD）稳定期肺肾两虚证的临床疗效。方法：将50例COPD肺肾两虚证患者随机分为治疗组与对照组，每组各25例。对照组予以西医常规治疗，治疗组在对照组基础上加用加味金水六君煎治疗，2组均连续治疗4周，于治疗前后观察2组治疗前后中医证候积分、慢性阻塞性肺疾病评估测试（COPD assessment test，CAT）评分、6分钟步行距离（six-minute walking distance，6MWD）、第一秒用力呼气容积占预计值百分比（forced expiratory volume in one second percent predicted，FEV1%）、第一秒用力呼气容积与用力肺活量比值（ratio of forced expiratory volume in one second to forced vital capacity，FEV1/FVC），并评价临床疗效。结果：总有效率治疗组为96.00%（24/25），对照组为84.00%（21/25），2组比较，差异有统计学意义（P<0.05）。2组中医证候积分、CAT评分、6MWD、FEV1%、FEV1/FVC值治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.05或P<0.01）。结论：加味金水六君煎联合西医常规治疗可有效改善COPD稳定期肺肾两虚证患者的临床症状，值得临床推广。 |
| 关键词: 慢性阻塞性肺疾病 肺胀 肺肾两虚证 稳定期 加味金水六君煎 中西医结合疗法 |
| DOI： |
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| Clinical effect of Jiawei Jinshui Liujun decoction in treatment of stable chronic obstructive pulmonary disease with lung-kidney deficiency: An analysis of 25 cases |
| YANG Changgui,YAO Hongyan |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, Hunan, China;Hunan University of Chinese Medicine, Changsha 410208, Hunan, China) |
| Abstract: |
| Objective： To investigate the clinical effect of Jiawei Jinshui Liujun decoction in the treatment of stable chronic obstructive pulmonary disease （COPD） with lung-kidney deficiency. Methods： A total of 50 COPD patients with lung-kidney deficiency were randomly divided into treatment group and control group, with 25 patients in each group. The patients in the control group received conventional Western medicine treatment, while those in the treatment group received Jiawei Jinshui Liujun decoction in addition to the treatment in the control group, and both groups were treated for 4 consecutive weeks. The two groups were observed in terms of traditional Chinese medicine （TCM） syndrome score, COPD assessment test （CAT） score, 6-minute walk distance （6MWD）, percentage of forced expiratory volume in 1 second （FEV1%）, and the ratio of forced expiratory volume in one second to forced vital capacity （FEV1/FVC）, and clinical outcome was assessed for both groups. Results： There was a significant difference in overall response rate between the treatment group and the control group ［96.00% （24/25） vs 84.00% （21/25）, P < 0.05］. Both groups had significant changes in TCM syndrome score, CAT score, 6MWD, FEV1%, and FEV1/FVC value after treatment, with significant differences between the two groups after treatment （ P < 0.05 or P < 0.01）. Conclusion： Jiawei Jinshui Liujun decoction combined with conventional Western medicine treatment can effectively improve the clinical symptoms of patients with lung-kidney deficiency in the stable stage of COPD, and therefore, it holds promise for clinical application. |
| Key words: chronic obstructive pulmonary disease lung distension lung-kidney deficiency stable stage Jiawei Jinshui Liujun decoction integrated traditional Chinese and Western medicine therapy |
