| 摘要: |
| 目的：分析国医大师刘尚义教授治疗阴虚证的用药规律。方法：收集2018年1月1日至2023年1月1日刘教授门诊治疗阴虚证的医案，应用古今医案云平台V2.1分析中医诊断、西医诊断、中医证型、治则治法、用药频次等。结果：纳入6300则医案，阴虚证多见于50~59、40~49、60~69岁3个年龄段；中医证候出现频次排名前3位的中医诊断为肺积、肠蕈、乳岩；西医诊断出现频次排名前3位的疾病为肺癌、肠癌、乳腺癌；中医证型出现频次排名前3位的为肝肾阴虚证、阴虚毒热证、阴虚燥热证；治则治法排名前3位的依次为补益肝肾、养阴清热解毒、滋润润燥；使用频次>480次排名前10位的中药分别是醋莪术、醋鳖甲、冬凌草、山茱萸、葎草、酒黄精、猫爪草、百合、炒芥子、醋龟甲； 通过对中药药对关联分析，药物同现频次>1880次的药对共20组，3味药核心组合8组，得到4个新处方。结论：通过挖掘分析得出刘教授治疗阴虚证的核心药物、治则治法及临证思路，总结出“补益肝肾”的核心治疗法则。 |
| 关键词: 阴虚证 数据挖掘 用药规律 刘尚义 |
| DOI： |
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| Medication rule of National Chinese Medicine Master Liu Shangyi in treatment of Yin deficiency syndrome：A study based on data mining |
| LI Juan,TANG Dongxin,WU Wenyu |
| (The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550001，Guizhou，China) |
| Abstract: |
| Objective：To investigate the medication rule of National Chinese Medicine Master Professor Liu Shangyi in the treatment of Yin deficiency syndrome.Methods：Medical records were collected from the patients with Yin deficiency syndrome who were treated at the outpatient service of Professor Liu from January 1，2018 to January 1，2023，and Cloud Platform of Ancient and Modern Medical Records V2.1 was used to analyze traditional Chinese medicine (TCM) diagnosis，Western medicine diagnosis，TCM syndrome types，principles and methods of treatment，and frequency of medication.Results：A total of 6300 medical records were included.Yin deficiency syndrome was more common in the three age groups of 50-59 years，40-49 years，and 60-69 years.The top three TCM diagnoses based on TCM syndrome were lung accumulation，colorectal cancer，and breast cancer，and the top three Western medicine diagnoses were lung cancer，intestinal cancer，and breast cancer.The top three TCM syndrome types were liver-kidney Yin deficiency，Yin deficiency and heat-toxicity syndrome，and Yin deficiency and dryness-heat syndrome.The top three principles and methods of treatment were tonifying the liver and the kidney，tonifying the kidney and nourishing Yin，and nourishing Yin，clearing heat，and detoxicating.The top ten TCM drugs in terms of frequency of use were vinegar-processed Curcuma zedoaria，vinegar-processed turtle shell，Rabdosia rubescens，Comus officinalis，Humulus scandens，wine-processed Polygonatum sibiricum，Ranunculus ternatus Thunb.，lily，fried Semen Sinapis，and vinegar-processed tortoise shell (with a frequency of >480 times).The association analysis of TCM drug combinations obtained 20 drug combinations with a co-occurrence frequency of >1880 times，as well as 8 core combinations with 3 drugs and 4 new prescriptions.Conclusion：Data mining analysis obtains the core drugs，principles and methods of treatment，and clinical practice thinking of Professor Liu in the treatment of Yin deficiency syndrome and summarizes the core treatment principle of tonifying the liver and the kidney. |
| Key words: Yin deficiency syndrome data mining medication rule Liu Shangyi |
