| 摘要: |
| 目的：观察息痛贴剂对瘀血阻络证偏头痛患者的临床疗效及降钙素基因相关肽(CGRP)、一氧化氮（NO）的影响。方法：经由随机途径将135 例患者分为3组，每组各45 例。对照1组采用息痛贴剂治疗，对照2组采用苯甲酸利扎曲普坦治疗，治疗组采用息痛贴剂联合苯甲酸利扎曲普坦治疗，疗程均为1周。比较3组治疗前后疼痛程度［采用疼痛数字分级法（NPIS）进行评价］及血清CGRP、NO水平，比较3组止痛起效时间及持续时间，评价综合疗效。结果：观察过程中脱落14例，其中治疗组4 例、对照1组5 例、对照2组5 例，最终完成研究方案者121 例。总有效率治疗组为87.80%（36/41），对照1组为82.50%（33/40），对照2组为62.50%（25/40），治疗组及对照1组均高于对照2组，差异有统计学意义（P<0.01或P<0.05）。治疗后，治疗组及对照1组血清CGRP、NO水平及止痛起效时间、止痛持续时间均优于对照2组，差异有统计学意义（P<0.05），治疗组与对照1组各项指标差异无统计学意义（P>0.05）。结论：息痛贴剂对偏头痛患者具有良好的镇痛作用，可缩短止痛起效时间、延长止痛持续时间，其镇痛机制可能与其能降低 CGRP、NO的活性有关。 |
| 关键词: 偏头痛 瘀血阻络证 息痛贴剂 苯甲酸利扎曲普坦 |
| DOI： |
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| Clinical effect of Xitong patch in treatment of migraine with blood stasis obstructing the collaterals：An analysis of 41 cases |
| HUANG Jiantao,CHE Xiongyu,GONG Qiuling |
| (Changde first traditional Chinese medicine Hospital，Changde 415000，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Xitong patch in the treatment of migraine with blood stasis obstructing the collaterals and its effect on calcitonin gene-related peptide (CGRP) and nitric oxide (NO).Methods：A total of 135 patients were randomly divided into control group 1，control group 2，and treatment group，with 45 patients in each group.The patients in the control group 1 received Xitong patch，those in the control group 2 received rizatriptan benzoate，and those in the treatment group received Xitong patch combined with rizatriptan benzoate，with a course of treatment of 1 week.The three groups were compared in terms of the degree of pain based on numerical pain intensity scale (NPIS) and serum levels of CGRP and NO before and after treatment，as well as the onset time and duration of pain-relieving treatment，and overall response was evaluated.Results：A total of 14 patients were lost to follow-up，with 4 patients in the treatment group，5 in the control group 1，and 5 in the control group 2，and finally 121 patients completed the treatment.The treatment group had a significantly higher overall response rate than the control groups 1 and 2 ［87.80% (36/41) vs 82.50% (33/40) and 62.50% (25/40)，P<0.01 or P<0.05］.Compared with the control group 2，the treatment group and the control group 1 had significantly better serum levels of CGRP and NO and onset time and duration of pain-relieving treatment (P<0.05)，and there were no significant differences in these indices between the treatment group and the control group 1 (P>0.05).Conclusion：Xitong patch has a good analgesic effect in patients with migraine and can shorten the onset time of pain-relieving treatment and prolong the duration of pain-relieving treatment，possibly by reducing the activity of CGRP and NO. |
| Key words: migraine blood stasis obstructing the collaterals Xitong patch rizatriptan benzoate |
