| 摘要: |
| 目的:基于数据挖掘探讨金哲教授治疗子宫腺肌病（AM）的用药经验和特点。方法:收集2020年9月1日至2022年2月28日于北京中医药大学东方医院金教授专家门诊诊治的AM患者的首诊处方作为研究资料，建立中药处方数据库，利用Microsoft Excel 2010进行频次、性味归经分析，通过IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0对处方进行药物使用频次、性味归经、药物因子关联规则、复杂网络、系统聚类分析。结果:共纳入中药处方120首，涉及中药148味，常用药物有浙贝母、夏枯草、茯苓、金银花、三七、生牡蛎、香附、延胡索等，四气以寒、温、平为主，五味以甘、苦、辛为多，归经以肝、肾、肺经居多。关联规则提取到12对常用药对，20组常用药物组合，常用组方为川夏宁坤汤。结论:AM的基本病机为痰瘀互结于胞宫、冲任，积而成癥，痰浊瘀血是其治病之本，治疗以化痰散结、活血消癥为基本原则。 |
| 关键词: 子宫腺肌病 数据挖掘 用药规律 金哲 |
| DOI： |
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| Medication rule of Jin Zhe in treatment of adenomyosis: A study based on data mining |
| XIANG Lizhu,LI Yunbo,HUANG Haitao |
| (The Third Affiliated Hospital of Beijing University of Chinese Medicine，Beijing 100029，China;Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China) |
| Abstract: |
| Objective: To investigate the medication experience and features of Professor Jin Zhe in the treatment of adenomyosis (AM) based on data mining.Methods: Prescriptions at initial diagnosis were collected from the patients with AM who were diagnosed and treated at the outpatient service of Professor Jin Zhe in Dongfang Hospital，Beijing University of Chinese Medicine，from September 1st，2020 to February 28th，2022，and a database was established for traditional Chinese medicine (TCM) prescriptions.Microsoft Excel 2010 was used for the analysis of frequency，nature，taste，and meridian entry，and IBM SPSS Modeler 18.0 and IBM SPSS Statistics 25.0 was used for the analysis of prescriptions in terms of frequency of use，nature/taste/meridian entry，drug factor association rule，complex network，and hierarchical cluster analysis.Results: A total of 120 TCM prescriptions were included，involving 148 TCM drugs.Commonly used drugs included Fritillaria thunbergii，Prunella vulgaris，Poria cocos，Lonicera japonica，Panax notoginseng，raw oyster shell，Rhizoma Cyperi，and Rhizoma Corydalis.Most drugs were cold，warm or neutral in nature and had a sweet，bitter or pungent taste，and they mainly entered the liver，kidney，and lung meridians.The association rule analysis obtained 12 commonly used drug combinations，and Chuanxia Ningkun decoction was the commonly used prescription.Conclusion: The basic pathogenesis of AM is intermingled phlegm and blood stasis at the uterus and the thoroughfare-conception meridian，which accumulates to form the disease，and turbid phlegm and blood stasis are the root for treatment.Removing phlegm，resolving static blood，and activating blood circulation are the main principles for the treatment of AM. |
| Key words: adenomyosis data mining medication rule Jin Zhe |
