| 摘要: |
| 目的：运用网络药理学及分子对接方法探究银地消庀汤治疗银屑病的潜在机制。方法：通过TCMSP平台、GeneCards等数据库获得银地消庀汤的活性成分、药物靶点、疾病靶点，将药物靶点、疾病靶点取交集获得共同靶点，构建“药物-活性成分-共同靶点”网络及蛋白质-蛋白质相互作用网络，并进行基因本体功能和京都基因与基因组百科全书通路富集分析。结果：银地消庀汤包含槲皮素、山柰酚、木犀草素等248种活性成分，涉及219个共同靶点，富集分析主要涉及调节脂质与动脉粥样硬化、肿瘤坏死因子信号通路、白细胞介素-17信号通路。结论：银地消庀汤治疗银屑病的潜在药理学机制及其活性化合物可能与脂质代谢、免疫调节、炎症诱导等多途径协同调节有关。 |
| 关键词: 银屑病 银地消庀汤 网络药理学 分子对接 |
| DOI： |
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| Potential mechanism of Yindi Xiaopi decoction in treatment of psoriasis: A study based on network pharmacology and molecular docking |
| MA Fei,XUE Song |
| (Guoyang Hospital of Traditional Chinese Medicine，Guoyang 233600，Anhui，China;The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine，Nanchang 330006，Jiangxi，China) |
| Abstract: |
| Objective: To investigate the potential mechanism of Yindi Xiaopi decoction in the treatment of psoriasis based on network pharmacology and molecular docking.Methods: Databases including TCMSP and GeneCards were searched to obtain the active components of Yindi Xiaopi decoction，drug targets，and disease targets，and the drug targets and the disease targets were intersected to obtain the common targets.A drug-active component-common target network and a protein-protein interaction network were constructed，and gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed.Results: A total of 248 active components were obtained for Yindi Xiaopi decoction，including quercetin，kaempferol，and luteolin，which involved 219 common targets.Enrichment analyses showed that they were mainly involved in the lipid and atherosclerosis pathway，the tumor necrosis factor signaling pathway，and the interleukin-17 signaling pathway.Conclusion: The potential pharmacological mechanism and active compounds of Yindi Xiaopi decoction in the treatment of psoriasis may be associated with the synergistic regulation of multiple pathways such as lipid metabolism，immunoregulation，and inflammation induction. |
| Key words: psoriasis Yindi Xiaopi decoction network pharmacology molecular docking |
