| 摘要: |
| 目的：探讨国医大师潘敏求教授治疗胃癌的用药规律。方法：收集整理潘教授治疗胃癌的医案，采用古今医案云平台（V2.3.5）进行证型、证素、药物及组方规律等数据挖掘，归纳总结其辨治规律。结果：纳入的123则病案共涉及13种证型，拆分后得到实性病机证素6个，虚性病机证素4个，病位证素 4个，病机证素以气郁、气虚为主，病位证素以胃脘、脾为主。200首方剂中，共包含中药142味，多药性平、温，药味甘、苦、辛，归脾、肺、肝经；通过药物关联分析得到17对关联药物，通过聚类分析得到4类核心药物组合，通过复杂网络分析得到由甘草、白术、茯苓、黄芪等12味药物组成的治疗胃癌核心药物网络。结论：潘敏求教授认为胃癌病机为脾胃虚弱，临证组方注重健脾益气、疏肝理气、清热解毒等药物的运用，擅长攻补兼施，在临床上取得较好的疗效。 |
| 关键词: 胃癌 用药规律 数据挖掘 潘敏求 |
| DOI： |
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| Medication rule of National Chinese Medicine Master Pan Minqiu in treatment of gastric cancer |
| HE Shoushu,SONG Cheng,TANG Wei |
| (Hunan University of Chinese Medicine，Changsha 410208，Hunan，China;Hunan Cancer Hospital，Changsha 410013，Hunan，China;Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of National Chinese Medicine Master Pan Minqiu in the treatment of gastric cancer. Methods：The medical records of Professor Pan Minqiu in the treatment of gastric cancer were collected，and Cloud Platform of Ancient and Modern Medical Records (V2.3.5) was used for data mining in terms of syndrome type，syndrome element，drug，and prescription rule to summarize the rule in syndrome differentiation-based treatment. Results：A total of 13 syndrome types were involved in the 123 medical records included in the analysis，and further analysis obtained 6 excessive syndrome elements of pathogenesis，4 deficient syndrome elements of pathogenesis，and 4 syndrome elements of disease location，with Qi depression and Qi deficiency as the main syndrome elements of pathogenesis and gastric cavity and spleen as the main syndrome elements of disease location. The 200 prescriptions involved 142 TCM drugs; most drugs were neutral or warm in nature and had a sweet，bitter or pungent taste，and they mainly entered the spleen，lung，and liver meridians. The drug association analysis obtained 17 combinations of associated drugs，and the cluster analysis obtained 4 core drug combinations. The complex network analysis obtained a core drug network of 12 drugs in the treatment of gastric cancer，including Radix Glycyrrhizae，Atractylodes macrocephala Koidz.，Poria cocos，and Astragalus membranaceus. Conclusion：Professor Pan Minqiu thinks that deficiency of spleen and stomach is the pathogenesis of gastric cancer and focuses on the use of drugs for strengthening the spleen and benefiting Qi，soothing the liver and regulating Qi，and clearing heat and detoxicating in clinical practice，with the application of tonification and purgation in combination，which has achieved a good clinical effect in treatment. |
| Key words: gastric cancer medication rule data mining Pan Minqiu |
