| 摘要: |
| 目的：探讨归脾汤加减防治非小细胞肺癌化疗后骨髓抑制的临床效果。方法：将56例非小细胞肺癌患者随机分为治疗组和对照组,每组各28例。对照组采用吉西他滨+顺铂（GP）方案治疗,治疗组在对照组基础上加用归脾汤加减治疗,比较2组骨髓抑制情况、血常规（白细胞、血红蛋白、血小板水平）及Karnofsky功能状态（KPS）评分。结果：骨髓抑制发生率治疗组为57.14%（16/28）,低于对照组的85.71%(24/28),差异有统计学意义（P＜0.05）。2组白细胞、血红蛋白、血小板水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义（P＜0.05）。治疗后,治疗组KPS评分高于对照组,差异有统计学意义（P＜0.05）。结论：归脾汤加减可有效缓解非小细胞肺癌患者化疗后的骨髓抑制,改善血常规指标,降低骨髓抑制程度,提高生活质量。 |
| 关键词: 非小细胞肺癌 化疗 骨髓抑制 中西医结合疗法 归脾汤加减 |
| DOI： |
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| Clinical effect of modified Guipi decoction in prevention and treatment of bone marrow suppression after chemotherapy for non-small cell lung cancer：An analysis of 28 cases |
| PENG Wei |
| (Changsha Municipal Hospital of Traditional Chinese Medicine,Changsha 410199,Hunan,China) |
| Abstract: |
| Objective：To investigate the clinical effect of modified Guipi decoction in the prevention and treatment of bone marrow suppression after chemotherapy for non-small cell lung cancer.Methods：A total of 56 patients with non-small cell lung cancer were randomly divided into treatment group and control group,with 28 patients in each group.The patients in the control group were given the gemcitabine+cisplatin regimen,and those in the treatment group were given modified Guipi decoction in addition to the treatment in the control group.The two groups were compared in terms of bone marrow suppression,routine blood test results (white blood cell count,hemoglobin,and platelet level),and Karnofsky Performance Scale (KPS) score.Results：The treatment group had a significantly lower bone marrow suppression rate than the control group ;57.14% (16/28) vs 85.71% (24/28),P<0.05］.After treatment,both groups had significant changes in white blood cell count,hemoglobin,and platelet level,and there were significant differences in these indices between the two groups after treatment (P<0.05).After treatment,the treatment group had a significantly higher KPS score than the control group (P<0.05).Conclusion：In patients with bone marrow suppression after chemotherapy for non-small cell lung cancer,Guipi decoction can effectively alleviate symptoms,improve routine blood test results,reduce the degree of bone marrow suppression,and enhance quality of life. |
| Key words: non-small cell lung cancer chemotherapy bone marrow suppression integrated traditional Chinese and Western medicine therapy Guipi decoction |
