| 摘要: |
| 目的：观察紫铜消白方联合泼尼松片治疗白癜风的临床疗效。方法：将110 例白癜风患者随机分为治疗组和对照组，每组各55 例。对照组采用泼尼松片治疗，治疗组在此基础上加用紫铜消白方治疗，疗程均为3个月。观察比较2组综合疗效，T淋巴细胞指标（CD4+、CD8+、CD4+/CD8+）水平，免疫功能指标［免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）］水平，皮肤病生活质量指数(DLQI)评分及不良反应发生情况。结果：总有效率治疗组为94.55%（52/55），对照组为81.82%（45/55），组间比较，差异有统计学意义（P<0.05）。2组T淋巴细胞指标水平、免疫球蛋白指标水平、DLQI评分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P<0.05或P<0.01）。药物不良反应发生率治疗组为3.64%（2/55），低于对照组的14.55%（8/55），差异有统计学意义（P<0.05）。结论：紫铜消白方联合泼尼松片治疗白癜风能够提高临床疗效，改善患者免疫功能和生活质量，且不良反应少，值得临床推广应用。 |
| 关键词: 白癜风 中西医结合疗法 紫铜消白方 泼尼松片 |
| DOI： |
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| Clinical effect of Zitong Xiaobai prescription combined with prednisone tablets in treatment of leucoderma：A analysis of 55 cases |
| LI Xiaosha |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410005，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Zitong Xiaobai prescription combined with prednisone tablets in the treatment of leucoderma.Methods：A total of 110 patients with leucoderma were randomly divided into treatment group and control group，with 55 patients in each group.The patients in the control group were treated with prednisone tablets，while those in the treatment group were treated with Zitong Xiaobai prescription in addition to the treatment in the control group，and the course of treatment was 3 months for both groups.The two groups were compared in terms of overall response，T lymphocytes (CD4++，CD8+，and CD4+/CD8+)，immune function parameters ［immunoglobulin A (IgA)，immunoglobulin G (IgG)，and immunoglobulin M (IgM)］，dermatology life quality index (DLQI) score，and adverse reactions.Results：There was a significant difference in overall response rate between the treatment group and the control group ［94.55% (52/55) vs 81.82% (45/55)，P<0.05］.After treatment，both groups had significant changes in T lymphocytes，immunoglobulins，and DLQI score，and there were significant differences in these indicators between the two groups after treatment (P<0.05 or P<0.01).The treatment group had a significantly lower incidence rate of adverse drug reactions than the control group ［3.64% (2/55) vs 14.55% (8/55)，P<0.05］.Conclusion：In the treatment of leucoderma，Zitong Xiaobai prescription combined with prednisone tablets can improve clinical outcome and enhance immune function and quality of life，with few adverse reactions，and therefore，it holds promise for clinical application. |
| Key words: leucoderma integrated traditional Chinese and Western medicine therapy Zitong Xiaobai prescription prednisone tablets |
