| 摘要: |
| 目的：基于数据挖掘技术探析现代湖湘名中医治疗肺癌的用药规律。方法：通过计算机检索2000年1月1日至2023年5月31日中国知网（CNKI）、万方数据(WANFANG DATA)、维普中文科技期刊数据库（VIP）中关于现代湖湘名中医治疗肺癌的相关病案，使用Excel 2016、IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0软件进行药物频次、性味归经、功效、关联规则及核心药物聚类分析。结果：共纳入处方111首，中药290味，累计用药频次为1690次。高频药物24味（使用频次≥18次），排前10位的药物依次为甘草、黄芪、白花蛇舌草、法半夏、茯苓、白术、浙贝母、麦冬、桑白皮、半枝莲。四气以寒、温、平为主；五味以苦、甘、辛为主；归经以归肝、肺、胃、脾经为主，功效以活血散瘀、行气止痛、清热解毒为主。关联规则分析得到核心药物26组，其中二联组合2组，三联组合24组。聚类分析得到核心组方5首。结论：现代湖湘名中医论治肺癌多从肝、肺、胃、脾论治，选用苦寒之品清热解毒，辅以甘温之品补益正气，治以活血散瘀、行气止痛、清热解毒、扶正益气为法，为肺癌的临床治疗提供了依据与参考。 |
| 关键词: 肺癌 现代湖湘名中医 中医药疗法 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of famous modern Huxiang doctors in treatment of lung cancer：A study based on data mining |
| LIU Zhen,LIU Xinyi,JIN Yuchen |
| (Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China;The Affiliated Hospital of Hunan Academy of Chinese Medicine，Changsha 410006，Hunan，China) |
| Abstract: |
| Objective：To investigate the medication rule of famous modern Huxiang doctors in the treatment of lung cancer based on data mining.Methods：CNKI，Wanfang Data，and VIP were searched for the medical records of lung cancer treated by famous modern Huxiang doctors published from January 1，2000 to May 31，2023，and Excel 2016，IBM SPSS Modeler 18.0，and IBM SPSS Statistics 25.0 were used to perform the analyses of drug frequency，nature，taste，meridian entry，and function，association rule analysis，and the cluster analysis of core drugs.Results：A total of 111 prescriptions were included，involving 290 traditional Chinese medicine drugs，with a total frequency of 1690 times.There were 24 high-frequency drugs (with a frequency of use of ≥18 times)，and the top 10 drugs were Radix Glycyrrhizae，Astragalus membranaceus，Hedyotis diffusa，Rhizoma Pinelliae Praeparatum，Poria cocos，Atractylodes macrocephala Koidz.，Fritillaria thunbergii，Radix Ophiopogonis，white mulberry root-bark，and Scutellaria barbata.Most drugs were cold，warm or neutral in nature and had a bitter，sweet or pungent taste and mainly entered the liver，lung，stomach，and spleen meridians，and their main functions included activating blood，dissipating stasis，promoting qi circulation clearing heat，and detoxicating.The association rule analysis obtained 26 combinations of core drugs，with 2 two-drug combinations and 24 three-drug combinations.The cluster analysis obtained 5 core prescriptions.Conclusion：Famous modern Huxiang doctors mainly treat lung cancer from the liver，lung，stomach，and spleen and use bitter and cold drugs for clearing heat and detoxicating，with the help of sweet and warm-natured drugs for tonifying vital Qi，and the main treatment methods include activating blood and dissipating stasis,relieving pain，clearing heat and detoxicating，and strengthening vital Qi and tonifying Qi，which provides a reference for the clinical treatment of lung cancer. |
| Key words: lung cancer famous modern Huxiang doctors traditional Chinese medicine treatment data mining medication rule |
