| 摘要: |
| 目的：观察十二味乌梅汤治疗丑时夜醒型失眠的临床疗效。方法：将睡眠持续困难、以丑时（1∶00~3∶00）夜醒为主症的失眠志愿者148 例随机分为治疗组（74 例）、对照1组（37 例）、对照2组（37 例）。治疗组采用十二味乌梅汤加西药安慰剂治疗，对照1组采用艾司唑仑加中药安慰剂治疗，对照2组采用西药安慰剂加中药安慰剂治疗，比较3组治疗前后中医证候积分、匹兹堡睡眠指数量表（PSQI）积分、不良反应和临床疗效。结果：治疗组、对照1组、对照2组总有效率分别为98.65%（73/74）、67.57%（25/37）、5.41%（2/37），治疗组与对照1组、对照2组比较，以及对照1组与对照2组比较，差异均有统计学意义（P＜0.05）。治疗后，治疗组较本组治疗前中医证候积分、PSQI积分均有所降低，且与对照1组、对照2组比较，差异均有统计学意义（P＜0.01）。3组在治疗过程中均未出现不良反应。结论：十二味乌梅汤治疗睡眠持续困难、丑时夜醒型失眠的患者，不仅能提高其睡眠质量，还可显著改善诸多伴随症状，具有较好的临床适用性。 |
| 关键词: 失眠 丑时夜醒 十二味乌梅汤 中医证候积分 匹兹堡睡眠指数量表 |
| DOI： |
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| Clinical effect of twelve-ingredient Fructus Mume decoction in treatment of insomnia with nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.：A analysis of 74 cases |
| LU Suqin,GU Zhishan,WU Zhen |
| (Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine/Zhenjiang Hospital of Traditional Chinese Medicine，Zhenjiang 212000，Jiangsu，China;Wuxi Huishan Hospital of Traditional Chinese Medicine，Wuxi 214100，Jiangsu，China) |
| Abstract: |
| Objective：To investigate the clinical effect of twelve-ingredient Fructus Mume decoction in the treatment of insomnia with nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.Methods：A total of 148 volunteers with insomnia who had the main symptoms of persistent difficulties in sleeping and nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.were enrolled and randomly divided into treatment group with 74 volunteers，control group 1 with 37 volunteers，and control group 2 with 37 volunteers.The volunteers in the treatment group were given twelve-ingredient Fructus Mume decoction combined with Western medicine placebo，those in the control group 1 were given estazolam combined with traditional Chinese medicine (TCM) placebo，and those in the control group 2 were given Western medicine placebo combined with TCM placebo.The three groups were compared in terms of TCM syndrome score，Pittsburgh Sleep Quality Index (PSQI) score，adverse reactions，and clinical outcome before and after treatment.Results：The overall response rate was 98.65% (73/74) in the treatment group，67.57% (25/37) in the control group 1，and 5.41% (2/37) in the control group 2，and there was a significant difference between the treatment group and the control groups 1/2 and between the control group 1 and the control group 2 (P＜0.05).After treatment，the treatment group had reductions in TCM syndrome score and PSQI score，and there were significant differences between the treatment group and the control groups 1/2 (P＜0.01).No adverse reactions were observed during treatment.Conclusion：In the treatment of insomnia with persistent difficulties in sleeping and nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.，twelve-ingredient Fructus Mume decoction can improve sleep quality and various accompanying symptoms and has good clinical applicability. |
| Key words: insomnia nighttime awakenings during the period of the day from 1 a.m.to 3 a.m. traditional Chinese medicine syndrome score Pittsburgh Sleep Quality Index |
