| 摘要: |
| 目的：基于数据挖掘分析吴力群教授治疗儿童咳嗽变异性哮喘（CVA）的用药规律。方法：收集吴教授门诊的63 例CVA患儿的处方信息，对中药进行频数描述性分析、关联规则分析、聚类分析及复杂网络分析。结果：共纳入192首中药处方，涉及135味药物，其中频次≥77次的中药有11味，前3味依次为炒莱菔子、生甘草、瓜蒌。关联规则15条，置信度最高的关联规则为茯苓-白芥子，炒莱菔子-白芥子，炒莱菔子-葶苈子，炒莱菔子-地龙、辛夷，黄芪-太子参、炒白术，胆南星-海浮石、橘红，瓜蒌-桑白皮、胆南星等；支持度最高的关联规则为炒莱菔子-苦杏仁，炒莱菔子-茯苓，瓜蒌-苦杏仁，炒莱菔子-银柴胡，炒莱菔子-辛夷等。聚类分析得到3类药物。复杂网络分析显示，法半夏、陈皮、炒莱菔子、瓜蒌、甘草、苦杏仁、胆南星、茯苓、蜜紫菀等20味中药之间的关联程度最高。结论：吴教授治疗儿童CVA用药味数较少、用药种类较为集中，常用处方为加味六安煎加减。 |
| 关键词: 咳嗽变异性哮喘 儿童 中医药疗法 数据挖掘 用药规律 |
| DOI： |
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| Medication rule of Wu Liqun in treatment of children with cough variant asthma：A study based on data mining |
| ZHANG Yunqing,ZHANG Ningning,WU Liqun |
| (Beijing University of Chinese Medicine，Beijing 100029，China;Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China) |
| Abstract: |
| Objective：To investigate the medication rule of Professor Wu Liqun in the treatment of children with cough variant asthma (CVA) based on data mining.Methods：Prescriptions were collected from 63 children with CVA who were treated at the outpatient service of Professor Wu Liqun，and traditional Chinese medicine (TCM) drugs in these prescriptions were analyzed by frequency analysis，association rule analysis，cluster analysis，and complex network analysis.Results：A total of 192 TCM prescriptions were included，involving 135 drugs，among which 11 TCM drugs had a frequency of ≥77，and the top three drugs were stir-fried Semen Raphani，raw Radix Glycyrrhizae，and Fructus Trichosanthis.A total of 15 association rules were obtained，the association rules with the highest degree of confidence included Poria cocos-Semen Sinapis Albae，stir-fried Semen Raphani-Semen Sinapis Albae，stir-fried Semen Raphani-Semen Lepidii，stir-fried Semen Raphani-Pheretima-Flos Magnoliae，Astragalus membranaceus-Radix Pseudostellariae-stir-fried Atractylodes macrocephala Koidz.，Rhizoma Arisaematis Cum Bile-Os Costaziae-red tangerine peel，and Fructus Trichosanthis-Mori Cortex-Rhizoma Arisaematis Cum Bile，and the association rules with the highest degree of support included stir-fried Semen Raphani-Semen Armeniacae Amarum，stir-fried Semen Raphani-Poria cocos，Fructus Trichosanthis-Semen Armeniacae Amarum，stir-fried Semen Raphani-Radix Stellariae，and stir-fried Semen Raphani-Flos Magnoliae.The cluster analysis obtained 3 clusters of drugs.The complex network analysis showed the highest degree of association between 20 TCM drugs including Rhizoma Pinelliae Praeparatum，tangerine peel，stir-fried Semen Raphani，Fructus Trichosanthis，Radix Glycyrrhizae，Semen Armeniacae Amarum，Rhizoma Arisaematis Cum Bile，Poria cocos，and honey-fried Aster tataricus.Conclusion：Professor Wu often uses a few TCM drugs in the treatment of children with CVA，with modified Jiawei Liuan decoction as the commonly used prescription. |
| Key words: cough variant asthma child traditional Chinese medicine treatment data mining medication rule |
