| 摘要: |
| 目的：探讨不同提取工艺对复方银杏通脉口服液质量指标的影响。方法：采用微波提取、超声提取、醇与水回流提取3种工艺，通过正交试验法对复方银杏通脉口服液的处方进行提取，以总黄酮醇苷、二苯乙烯苷、丹酚酸B含量及干膏率作为考察指标，运用综合评分法进行质量指标的比较。结果：最佳工艺为醇与水回流提取，12倍量料液比，回流提取1 h，提取2次。结论：醇与水回流提取工艺优于微波提取及超声提取工艺，且该方法实际可行，成本可控，可实现大生产。 |
| 关键词: 复方银杏通脉口服液 提取工艺 质量指标 实验研究 |
| DOI： |
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| Influence of different extraction processes on quality indices of Compound Yinxing Tongmai oral liquid |
| LYU Zhenzhen,ZOU Qi,YANG Yong |
| (Hunan Busky Pharmaceutical Co.，Ltd.，Huaihua 418400，Hunan，China) |
| Abstract: |
| Objective：To investigate the influence of different extraction processes on the quality indices of Compound Yinxing Tongmai oral liquid.Methods：Based on an orthogonal design，the prescription of Compound Yinxing Tongmai oral liquid was extracted using microwave extraction，ultrasound extraction，and alcohol-water reflux extraction.With total flavonoid glycosides，stilbene glucoside，salvianolic acid B，and dry extract yield as the indicators for assessment，the comprehensive score method was used for comparison of quality indices.Results：The optimal process was alcohol-water reflux extraction，with a solid-liquid ratio of 12 folds，reflux extraction for 1 hour，and extraction twice.Conclusion：Alcohol-water reflux extraction is better than microwave extraction and ultrasound extraction and is practical and feasible with controllable costs，and therefore，it can be used to realize mass production. |
| Key words: Compound Yinxing Tongmai oral liquid extraction process quality index experimental study |
