| 摘要: |
| 目的：探讨中医药治疗慢性阻塞性肺疾病（COPD）的用药规律，以期为临床用药提供参考。方法：检索中国知网（CNKI）、万方数据（WANFANG DATA）、维普中文科技期刊数据库（VIP），筛选中医药治疗COPD的文献，建立方剂数据库，采用IBM SPSS Modeler 18.0软件进行关联规则分析，采用Cytoscape 3.7.2软件构建核心药物网络图，采用SPSS Statistics 21.0 软件进行系统聚类分析及因子分析。结果：共纳入处方331首，涉及药物231味，总用药频次3606次。COPD证型以痰热壅肺证、肺肾两虚证、痰浊壅肺证、肺脾气虚证、痰瘀阻肺证等为主。症状以咳嗽、喘息、咳痰、胸闷、呼吸困难、气短、发热、乏力等为主。高频药物有茯苓、苦杏仁、甘草、法半夏等。药物四气以温热性为主，药味以甘、苦、辛味为主，多归肺、肝、脾、胃经。以补虚药应用最多，其次是化痰止咳平喘药等。关联规则分析发现关联强度较高的规则有20条，系统聚类分析得出4个新处方，因子分析可提取公因子9个。结论：中医药治疗COPD以化痰止咳、补虚、利水、理气、活血等为基本治则进行组方配伍。 |
| 关键词: 慢性阻塞性肺疾病 证型 症状 用药规律 |
| DOI： |
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| Medication rule for chronic obstructive pulmonary disease：A study based on “syndrome-symptom-prescription-drug” |
| YANG Ping,QU Jilan |
| (Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，Gansu，China;Gansu Provincial People’s Hospital，Lanzhou 730013，Gansu，China) |
| Abstract: |
| Objective：To investigate the medication rule in traditional Chinese medicine (TCM) treatment of chronic obstructive pulmonary disease (COPD)，and to provide a reference for clinical medication.Methods：CNKI，WANFANG DATA，and VIP were searched for articles on TCM treatment of COPD，and a database was established for related prescriptions.IBM SPSS Modeler 18.0 software was used for association rule analysis，Cytoscape 3.7.2 software was used to construct a core drug network，and SPSS Statistics 21.0 software was used for hierarchical cluster analysis and factor analysis.Results：A total of 331 prescriptions were included，involving 231 TCM drugs，with a total frequency of 3606.The main syndrome types of COPD included syndrome of phlegm-heat obstructing the lung，syndrome of lung-kidney deficiency,syndrome of turbid phlegm obstructing the lung，syndrome of lung-spleen Qi deficiency，and syndrome of phlegm and blood stasis obstructing the lung，and the main symptoms included cough，wheezing，expectoration，chest distress，dyspnea，short breath，pyrexia，and weakness.High-frequency drugs included Poria cocos，Semen Armeniacae Amarum，Radix Glycyrrhizae，and Rhizoma Pinelliae Praeparatum.Most TCM drugs were warm or hot in nature and had a sweet，bitter or pungent taste，and they mainly entered the lung，liver，spleen，and stomach meridians.Deficiency-tonifying herbs were the most frequently used drugs，followed by phlegm-eliminating，cough-relieving，and asthma-relieving drugs.The association rule analysis showed 20 rules with a relatively high strength of association，the hierarchical cluster analysis obtained 4 new prescriptions，and the factor analysis obtained 9 common factors.Conclusion：In TCM treatment of COPD，compatibility of prescriptions is determined based on the principles of removing phlegm and relieving cough，tonifying deficiency，promoting diuresis，regulating Qi，and activating blood circulation. |
| Key words: chronic obstructive pulmonary disease syndrome type symptom medication rule |
