| 摘要: |
| 目的：观察加味归芍异功散合西药四联疗法治疗脾胃虚弱型幽门螺杆菌（Hp）相关性慢性胃炎的临床疗效。方法：将60 例Hp相关性慢性胃炎脾胃虚弱证患者按照随机数字表法分为治疗组和对照组，每组各30 例。治疗组采用加味归芍异功散合西药四联疗法治疗，对照组仅采用西药四联疗法治疗，比较2组的中医证候疗效、Hp根除情况、中医证候评分（胃脘隐痛、胃脘胀满、乏力、纳呆、气短、大便稀溏）以及不良反应发生情况。结果：中医证候疗效总有效率治疗组为100.00%（30/30），对照组为93.34%（28/30），2组比较，差异有统计学意义（P<0.01）；Hp根除总有效率治疗组为100.00%（30/30），对照组为80.00%（24/30），2组比较，差异有统计学意义（P<0.05）；2组治疗后中医证候各项评分均较治疗前下降，且治疗组下降幅度较对照组更大（P<0.05）；不良反应发生率治疗组为6.67%（2/30），对照组为20.00%（6/30），组间比较，差异无统计学意义（P>0.05）。结论：加味归芍异功散合西药四联疗法治疗Hp相关性慢性胃炎脾胃虚弱证的临床疗效优于单用四联疗法，值得临床推广应用。 |
| 关键词: Hp相关性慢性胃炎 脾胃虚弱证 加味归芍异功散 四联疗法 |
| DOI： |
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| Clinical effect of Jiawei Guishao Yigong powder combined with Western medicine quadruple therapy in treatment of Helicobacter pylori-associated chronic gastritis：An analysis of 30 cases |
| ZHANG Jianyun,HE Lijuan,YIN Ping |
| (Hunan Provincial Rehabilitation Hospital，Changsha 410007，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of Jiawei Guishao Yigong powder combined with Western medicine quadruple therapy in the treatment of Helicobacter pylori (Hp)-associated chronic gastritis.Methods：A total of patients with Hp-associated chronic gastritis were divided into treatment group and control group using a random number table，with 30 patients in each group.The patients in the treatment group were given Jiawei Guishao Yigong powder combined with Western medicine quadruple therapy，and those in the control group were given Western medicine quadruple therapy alone.The two groups were compared in terms of the treatment outcome of TCM syndrome，TCM syndrome scores (dull stomachache，gastric distension，weakness，poor appetite，short breath，and loose stool)，and the incidence rate of adverse reactions.Results：There were significant differences between the treatment group and the control group in the overall response rates of TCM syndrome［100.00% (30/30) vs 93.34% (28/30)，P<0.01］ and Hp eradication［100.00% (30/30) vs 80.00% (24/30)，P<0.05］.After treatment，both groups had significant reductions in each TCM syndrome score，and the treatment group had significantly greater reductions than the control group.There was no significant difference in the incidence rate of adverse reactions between the treatment group and the control group［6.67% (2/30) vs 20.00% (6/30)，P>0.05］.Conclusion：Jiawei Guishao Yigong powder combined with Western medicine quadruple therapy has a better clinical effect than quadruple therapy alone in the treatment of Hp-associated chronic gastritis and thus holds promise for clinical application. |
| Key words: Helicobacter pylori-associated chronic gastritis deficiency of spleen and stomach Jiawei Guishao Yigong powder quadruple therapy |
