| 摘要: |
| 目的：总结蒋益兰教授治疗大肠癌的用药规律与组方特色。方法：筛选2017年3月至2021年3月期间蒋教授门诊大肠癌患者的处方,使用中医传承计算系统平台（V3.0）中频次统计、关联规则、聚类分析等方法,分析蒋教授治疗大肠癌的用药规律。结果：纳入符合标准的处方共500首,涉及药物149味,用药频次居于前4位的分别为黄芪、法半夏、白术、茯苓;药物四气五味以苦寒、甘平、辛温为主,归经以肺、脾、胃经居多;挖掘出39组药物核心组合,频次排前3位的依次为黄芪-半枝莲、黄芪-郁金、黄芪-法半夏;药物关联规则分析得出29组核心药物和3首新处方。结论：蒋教授治疗大肠癌以健脾益气、扶助胃气为本,化瘀解毒、清热祛湿以攻邪,同时注重疏肝理气散结,分期论治,标本兼顾。 |
| 关键词: 大肠癌 用药规律 数据挖掘 蒋益兰 |
| DOI： |
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| Jiang Yilan’s medication rule in treatment of colorectal cancer：An analysis based on data mining |
| YI Tianxia,SONG Cheng,TANG Wei |
| (Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Hunan Cancer Hospital,Changsha 410013,Hunan,China;The Affiliated Hospital of Hunan Academy of Chinese Medicine,Changsha 410006,China) |
| Abstract: |
| Objective：To investigate Professor Jiang Yilan’s medication rule and prescription features in the treatment of colorectal cancer based on data mining.Methods：Prescriptions were collected from the patients with colorectal cancer who attended the outpatient service of Professor Jiang Yilan from March 2017 to March 2021.Based on the Traditional Chinese Medicine Inheritance Support System (V3.0),the methods such as frequency statistics,association rule,and cluster analysis were used to investigate Professor Jiang Yilan’s medication rule in the treatment of colorectal cancer.Results：A total of 500 prescriptions meeting the criteria were included,which involved 149 drugs.The top 4 drugs in terms of frequency were Astragalus membranaceus,Rhizoma Pinelliae Praeparatum,Atractylodes macrocephala Koidz.,and Poria cocos.As for the four natures and five flavors of drugs,most drugs were bitter and cold,sweet and mild,and pungent and warm,and as for meridian entry,most drugs acted on the lung,spleen,and stomach meridians.A total of 39 core drug combinations were obtained,and the top 3 combinations in terms of frequency were Astragalus membranaceus-Scutellaria barbata,Astragalus membranaceus-Curcuma aromatica,and Astragalus membranaceus-Rhizoma Pinelliae Praeparatum.Association rule analysis obtained 29 core drugs and 3 new prescriptions.Conclusion：In the treatment of colorectal cancer,Professor Jiang Yilan focuses on strengthening the spleen,benefiting Qi,and supporting stomach Qi and applies blood stasis-removing and detoxicating therapy and heat-clearing and dampness-eliminating therapy to attack pathogens.Professor Jiang Yilan also emphasizes the importance of soothing the liver,regulating Qi,and resolving static blood,as well as treatment by stage and treatment of both manifestation and root cause of disease. |
| Key words: colorectal cancer medication rule data mining Jiang Yilan |
