摘要: |
目的:观察安神解郁汤联合耳穴刺激对肝气郁结型卒中后抑郁(PSD)的临床疗效及其对血清单胺类神经递质的影响。方法:将80 例肝气郁结型PSD患者随机分为治疗组与对照组,每组各40 例。治疗组予安神解郁汤联合耳穴刺激治疗,对照组予盐酸氟西汀胶囊治疗,2组疗程均为8周。比较2组汉密尔顿抑郁量表(HAMD)积分、美国国立卫生研究院卒中量表(NIHSS)积分、中医证候积分、血清单胺类神经递质水平和临床疗效,并记录2组不良反应发生情况。结果:总有效率治疗组为95.0%(38/40),对照组为75.0%(30/40),2组比较,差异有统计学意义(P<0.05)。2组HAMD积分、NIHSS积分、中医证候积分、血清单胺类神经递质水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义(均P<0.05);对照组不良反应发生率为20.0%(8/40),治疗组未出现明显不良反应。结论:安神解郁汤联合耳穴刺激治疗肝气郁结型PSD疗效良好,能明显提高患者血清单胺类神经递质水平,且无明显不良反应,值得临床推广。 |
关键词: 安神解郁汤 耳穴刺激 卒中后抑郁 氟西汀 单胺类神经递质 |
DOI: |
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Clinical effect of Anshen Jieyu decoction combined with auricular point stimulation in treatment of post-stroke depression with stagnation of liver Qi:An analysis of 40 cases |
XU Hui,CHEN Jianhong |
(The Fourth Hospital of Changsha,Changsha 410006,Hunan,China;Hengyang Hospital of Traditional Chinese Medicine,Hengyang 421001,Hunan,China) |
Abstract: |
Objective:To investigate the clinical effect of Anshen Jieyu decoction combined with auricular point stimulation in the treatment of post-stroke depression (PSD) with stagnation of liver Qi and its effect on serum monoamine neurotransmitter.Methods:A total of 80 PSD patients with stagnation of liver Qi were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the treatment group were given Anshen Jieyu decoction combined with auricular point stimulation,and those in the control group were given fluoxetine hydrochloride capsules.The course of treatment was 8 weeks for both groups.The two groups were compared in terms of Hamilton Depression Scale (HAMD) score,NIH Stroke Scale (NIHSS) score,traditional Chinese medicine (TCM) syndrome score,serum level of monoamine neurotransmitter,and clinical outcome,and adverse events were recorded for both groups.Results:There was a significant difference in overall response rate between the treatment group and the control group [95.0% (38/40) vs 75.0% (30/40),P<0.05].Both groups had significant changes in HAMD score,NIHSS score,TCM syndrome score,and the serum level of monoamine neurotransmitter after treatment,and there were significant differences in these indicators between the two groups after treatment (all P<0.05).The incidence rate of adverse events was 20.0% (8/40) in the control group,while no obvious adverse event was observed in the treatment group.Conclusion:Anshen Jieyu decoction combined with auricular point stimulation has a marked clinical effect in the treatment of PSD with stagnation of liver Qi and can significantly increase the serum level of monoamine neurotransmitter,with little adverse effect,and therefore,it holds promise for clinical application. |
Key words: Anshen Jieyu decoction auricular point stimulation post-stroke depression fluoxetine monoamine neurotransmitter |