摘要: |
目的:优选补肾健骨凝胶的制备工艺。方法:采用正交试验法,以干膏得量、补骨脂素、异补骨脂素含量为评价指标,优选最佳提取工艺;以外观形态、凝胶初黏度、pH值、指标成分累积渗透量为指标,分别将空白基质、中和剂及促渗剂进行筛选。结果:最佳提取工艺为按处方比例,称取除龙血竭外的补骨脂等5味药材,提取3次,第1次加8倍量80%乙醇,第2、3次分别加8倍量水,每次提取1 h。卡波姆、三乙醇胺、月桂氮卓酮的用量分别为制成量的1%、2%、2%。结论:制得的凝胶质地光滑细腻、药物分散良好。 |
关键词: 补肾健骨凝胶 制备工艺 空白凝胶基质 中和剂 促渗剂 |
DOI: |
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Preparation process of Bushen Jiangu gel |
CHEN Xueting,XU Wenjie,LI Jiehuan |
(Guangdong Second Provincial Traditional Chinese Medicine Hospital & Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology,Guangzhou 510095,Guangdong,China) |
Abstract: |
Objective:To optimize the preparation process of Bushen Jiangu gel.Methods:With dry extract yield and the content of psoralen and isopsoralen as evaluation indices,the orthogonal test was used to determine the optimal extraction process,and blank matrix,neutralizers,and penetration enhancers were screened out based on the indices of appearance,initial viscosity of gel,pH value,and cumulative penetration of marker components.Results:The optimal extraction process was to weigh out the 5 medicinal materials (including Fructus Psoraleae) except dragon’s blood according to the prescription and extract 3 times,with 8-fold 80% ethanol for the first time and 8-fold water for the second and third times,for 1 hour each time.The amount of carbomer,triethanolamine,and laurocapram used accounted for 1%,2%,and 2%,respectively,of the finished amount.Conclusion:The gel prepared has smooth texture with good dispersion. |
Key words: Bushen Jiangu gel preparation process blank gel matrix neutralizer penetration enhancer |