| 摘要: |
| 目的：观察自拟健脾益胃汤治疗慢性萎缩性胃炎的临床效果。方法：按照随机数字表法将70 例慢性萎缩性胃炎患者分为治疗组和对照组，每组各35 例。对照组采用常规西药治疗，治疗组在对照组基础上加用自拟健脾益胃汤治疗。治疗结束后，比较2组综合疗效、治疗前后中医证候（胃痛、胃胀、纳差、嗳气、大便不畅）评分、血清炎性因子［肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）］水平以及不良反应发生率。结果：总有效率治疗组为94.29%（33/35），高于对照组的77.14%（27/35），2组差异有统计学意义（P<0.05）；2组治疗后中医各项证候评分及血清炎性因子各项指标水平均较治疗前降低，且治疗组均低于对照组，差异有统计学意义（P<0.01或P<0.05）；不良反应总发生率治疗组为5.71%（2/35），对照组为11.43%（4/35），2组差异无统计学意义（P＞0.05）。结论：自拟健脾益胃汤治疗慢性萎缩性胃炎疗效颇佳，能够明显改善患者的症状体征和炎症反应，且不良反应少，值得临床推广应用。 |
| 关键词: 慢性萎缩性胃炎 自拟健脾益胃汤 中医证候评分 炎性因子 不良反应 |
| DOI： |
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| Clinical effect of self-made spleen-strengthening and stomach-tonifying decoction in treatment of chronic atrophic gastritis：An analysis of 35 cases |
| YAN Yanyang |
| (Loudi Municipal Hospital of Traditional Chinese Medicine，Loudi 417000，Hunan，China) |
| Abstract: |
| Objective：To investigate the clinical effect of self-made spleen-strengthening and stomach-tonifying decoction in the treatment of chronic atrophic gastritis.Methods：A total of 70 patients with chronic atrophic gastritis were divided into treatment group and control group using a random number table，with 35 patients in each group.The patients in the control group were given conventional Western medicine treatment，and those in the treatment group were given self-made spleen-strengthening and stomach-tonifying decoction in addition to the treatment in the control group.The two groups were compared in terms of overall response，traditional Chinese medicine (TCM) syndrome scores (stomachache，stomach distension，poor appetite，belching，and inhibited defecation)，serum levels of inflammatory cytokines (tumor necrosis factor-α，interleukin-1β，and interleukin-8)，and incidence rate of adverse reactions.Results：The treatment group had a significantly higher overall response rate than the control group ［94.29% (33/35) vs 77.14% (27/35)，P<0.05］.After treatment，both groups had significant reductions in TCM syndrome scores and the serum levels of the above inflammatory cytokines，and the treatment group had significantly lower indices than the control group (P<0.01 or P<0.05).There was no significant difference in the incidence rate of adverse reactions between the treatment group and the control group ［5.71% (2/35) vs 11.43% (4/35)，P>0.05］.Conclusion：The self-made spleen-strengthening and stomach-tonifying decoction has a good clinical effect in the treatment of chronic atrophic gastritis and can significantly improve symptoms，signs，and inflammatory response with few adverse reactions，and therefore，it holds promise for clinical application. |
| Key words: chronic atrophic gastritis self-made spleen-strengthening and stomach-tonifying decoction traditional Chinese medicine syndrome score inflammatory cytokine adverse reaction |
