| 摘要: |
| 目的：观察自拟升阳化浊汤治疗气虚痰阻型慢性脑供血不足性眩晕的临床疗效。方法：将90 例气虚痰阻型慢性脑供血不足性眩晕患者随机分为3组,每组各30 例。治疗组采用自拟升阳化浊汤联合甲磺酸倍他司汀片治疗,对照1组单用甲磺酸倍他司汀片治疗,对照2组单用自拟升阳化浊汤治疗。治疗2周后,观察3组综合疗效、血液流学变指标（全血黏度、全血高切还原黏度、血浆黏度、全血低切还原黏度）及不良反应。结果：总有效率治疗组为93.3%（28/30）,高于对照1、2组的80.0%（24/30）、83.3%（25/30）,差异有统计学意义（P＜0.05）,而对照1、2组比较,差异无统计学意义（P＞0.05）。3组血液流变学各项指标治疗前后组内比较及治疗后治疗组与对照1、2组比较,差异均有统计学意义（P＜0.05）,而对照1、2组比较,差异无统计学意义（P＞0.05）。对照2组不良反应总发生率为6.7%（2/30）,低于治疗组、对照1组的30.0%（9/30）、23.3%（7/30）,差异有统计学意义（P＜0.05）。结论：自拟升阳化浊汤联合甲磺酸倍他司汀片治疗气虚痰阻型慢性脑供血不足性眩晕疗效好,能改善血液流变学指标,且安全性较高,具有临床应用价值。 |
| 关键词: 慢性脑供血不足性眩晕 气虚痰阻证 自拟升阳化浊汤 甲磺酸倍他司汀片 |
| DOI： |
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| Clinical effect of self-made Shengyang Huazhuo decoction in treatment of chronic cerebral circulation insufficiency vertigo with Qi deficiency and phlegm obstruction：An analysis of 30 cases |
| TAN Hua,PENG Xiaofei |
| (Chenzhou Municipal Hospital of Traditional Chinese Medicine,Chenzhou 423000,Hunan,China) |
| Abstract: |
| Objective：To investigate the clinical effect of self-made Shengyang Huazhuo decoction in the treatment of chronic cerebral circulation insufficiency vertigo with Qi deficiency and phlegm obstruction.Methods：A total of 90 patients with chronic cerebral circulation insufficiency vertigo with Qi deficiency and phlegm obstruction were randomly divided into treatment group,control group 1,and control group 2,with 30 patients in each group.The patients in the treatment group were given self-made Shengyang Huazhuo decoction combined with betahistine mesilate tablets,those in the control group 1 were given betahistine mesilate tablets alone,and those in the control group 2 were given self-made Shengyang Huazhuo decoction alone.After 2 weeks of treatment,the three groups were observed in terms of overall response,hemorheological indices (blood viscosity,high-shear whole blood viscosity reduction,plasma viscosity,and low-shear whole blood viscosity reduction),and adverse reactions.Results：The treatment group had a significantly higher overall response rate than the control groups 1 and 2 ［93.3% (28/30) vs 80.0% (24/30) and 83.3% (25/30),P<0.05］,while there was no significant difference between the control groups 1 and 2 (P>0.05).All groups had significant changes in hemorheological indices after treatment,and there were significant differences in these indices between the treatment group and the control groups 1 and 2 after treatment (P<0.05),while there were no significant differences between the control groups 1 and 2 (P>0.05).The control group 2 had a significantly lower overall incidence rate of adverse reactions than the treatment group and the control groups 1［6.7% (2/30) vs 30.0% (9/30) and 23.3% (7/30),P<0.05］.Conclusion：Self-made Shengyang Huazhuo decoction combined with betahistine mesilate tablets has a marked clinical effect and good safety in the treatment of chronic cerebral circulation insufficiency vertigo with Qi deficiency and phlegm obstruction and can improve hemorheological indices,and therefore,it holds for clinical application. |
| Key words: chronic cerebral circulation insufficiency vertigo Qi deficiency and phlegm obstruction self-made Shengyang Huazhuo decoction betahistine mesilate tablets |
