| 摘要: |
| 目的：观察益气活血方对射血分数保留型心力衰竭（HFpEF）患者进行干预后，其心功能、脑钠肽（BNP）、超敏C反应蛋白（hs-CRP）的变化情况。方法：将84 例HFpEF患者按照随机数字表法分为治疗组和对照组，每组各42 例。对照组采用西医标准化治疗方案，治疗组在对照组基础上给予益气活血方治疗，2组疗程均为4周。观察2组治疗前后心功能指标［包括心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）、左室射血分数（LVEF）、6 min步行试验（6MWT）］、BNP及hs-CRP的变化，并评价综合疗效。结果：总有效率治疗组为90.48%（38/42），对照组为80.95%（34/42），2组比较，差异有统计学意义（P＜0.05）。治疗后2组LVESD、LVEDD及血清BNP、hs-CRP水平均较治疗前降低，LVEF较治疗前升高，6MWT较治疗前增加，且治疗组各项指标改善情况均优于对照组，差异均有统计学意义（P＜0.05）。结论：益气活血方能够抑制HFpEF患者体内BNP和hs-CRP的表达，改善心功能指标，增加6MWT距离。 |
| 关键词: 射血分数保留型心力衰竭 益气活血方 心功能 脑钠肽 超敏C反应蛋白 |
| DOI： |
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| Effect of Qi-tonifying and blood-activating prescription on serum brain natriuretic peptide，high-sensitivity C-reactive protein， and cardiac function in patients with heart failure with preserved ejection fraction |
| GU Yawei,MO Yunqiu |
| (Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine，Nanning 530011，Guangxi，China) |
| Abstract: |
| Objective:To investigate the changes in cardiac function，brain natriuretic peptide (BNP)，and high-sensitivity C-reactive protein (hs-CRP)after intervention with Qi-tonifying and blood-activating prescriptionin patients with heart failure with preserved ejection fraction (HFpEF).Methods：A total of 84 patients with HFpEF were divided into treatment group and control group using a random number table，with 42 patients in each group.The patients in the control group were given standardized Western medicine treatment，and those in the treatment group were given Qi-tonifying and blood-activating prescription in addition to the treatment in the control group;the course of treatment was 4 weeks for both groups.The two groups were observed in terms of the changes in cardiac function parameters ［left ventricular end-systolic diameter (LVESD)，left ventricular end-diastolic diameter (LVEDD)，left ventricular ejection fraction (LVEF)，and six-minute walk test (6MWT)］，BNP，and hs-CRP，and overall response was evaluated.Results：There was a significant difference in overall response rate between the treatment group and the control group ［90.48%(38/42)vs 80.95%(34/42)，P＜0.05］.After treatment，both groups had significant reductions in LVESD，LVEDD，and serum levels of BNP and hs-CRP and significant increases in LVEF and 6MWT，and the treatment group had significantly better improvements than the control group (P＜0.05).Conclusion：For patients with HFpEF，Qi-tonifying and blood-activating prescription can inhibit the expression of BNP and hs-CRP，improve cardiac function parameters，and increase the distance of 6MWT. |
| Key words: heart failure with preserved ejection fraction Qi-tonifying and blood-activating prescription cardiac function brain natriuretic peptide high-sensitivity C-reactive protein |
