摘要: |
目的:探究泻心胶囊对瘀热互结型冠心病心绞痛患者的主要症状、炎症因子、血脂的影响。方法:选取60 例瘀热互结型冠心病心绞痛患者,将其随机分为治疗组和对照组,每组各30 例。对照组予以西医常规治疗,治疗组在对照组的基础上加用泻心胶囊治疗,疗程均为4周,比较2组治疗前后心绞痛疗效及炎症因子、血脂的变化。结果:心绞痛主要症状缓解总有效率治疗组为93.33%(28/30),对照组为83.33%(25/30),2组比较,差异有统计学意义(P<0.05)。2组细胞间黏附分子-1(ICAM-1)、C反应蛋白(CRP)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)治疗前后组内比较及治疗后组间比较,差异均有统计学意义(均P<0.05);与本组治疗前比较,治疗组HDL-C差异有统计学意义(P<0.05),而对照组差异无统计学意义(P>0.05),且治疗后组间比较,治疗组优于对照组,差异亦有统计学意义(P<0.05)。结论:泻心胶囊能够有效治疗瘀热互结型冠心病心绞痛,改善心绞痛主要症状,降低ICAM-1、CRP水平,改善血脂指标水平,值得临床推广。 |
关键词: 冠心病心绞痛 瘀热互结型 泻心胶囊 ICAM-1 CRP 血脂 |
DOI: |
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Clinical effect of Xiexin capsules in treatment of angina pectoris with intermingled stasis and heat:An analysis of 30 cases |
JIA Yixin,LI Ming,CHEN Xinyu |
(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China) |
Abstract: |
Objective:To investigate the effect of Xiexin capsules on the main symptoms,inflammatory factors,and blood lipids of patients with angina pectoris with intermingled stasis and heat.Methods:A total of 60 patients with angina pectoris with intermingled stasis and heat were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given conventional Western medicine treatment,and those in the treatment group were given Xiexin capsules in addition to the treatment in the control group.The course of treatment was 4 weeks for both groups,and the two groups were compared in terms of the treatment outcome of angina pectoris and the changes in inflammatory factors and blood lipids after treatment.Results:There was a significant difference in the overall remission rate of the main symptoms of angina pectoris between the treatment group and the control group [93.33% (28/30) vs 83.33% (25/30),P<0.05].Both groups had significant changes in intercellular adhesion molecule-1 (ICAM-1),C-reactive protein (CRP),total cholesterol,triglyceride,and low-density lipoprotein cholesterol after treatment,and there were significant differences in these indices between the two groups after treatment (all P<0.05).The treatment group had a significant change in high-density lipoprotein cholesterol (HDL-C) after treatment,while there was no significant change in the control group (P>0.05);the treatment group had a significantly better HDL-C level than the control group after treatment (P<0.05).Conclusion:Xiexin capsules have a marked clinical effect in the treatment of angina pectoris with intermingled stasis and heat and can improve the main symptoms of angina pectoris,reduce the levels of ICAM-1 and CRP,and improve blood lipid parameters.Therefore,it holds promise for clinical application. |
Key words: angina pectoris intermingled stasis and heat Xiexin capsules intercellular adhesion molecule-1 C-reactive protein blood lipids |